人巨细胞病毒感染与代谢综合征相关因素分析

Related factors of human cytomegalovirus infections in patients with metabolic syndrome

目的了解人巨细胞病毒（Human Cytomegalovurus，HCMV）在代谢综合征（Metabolic Syndrome MS）患者中的感染状况，探讨人巨细胞病毒感染与代谢综合征的相关性，为预防卒中及相关疾病提供临床指导。方法将2012年7—10月对海拔4100m的石渠县城各机关与事业单位工作人员680名体检资料进行分析，年龄16～58岁，男性407人，女性273人；观察其血液、体质量指数、血压、空腹血糖、甘油三酯、高密度脂蛋白胆固醇，并对其进行统计分析，均采用SPSS13．0软件包进行分析，均数±标准差，率的比较采用X2检验。结果680名工作人员中MS患者253例，患病率37．2％，其中男性164例患病率40．3％，女性89例患病率32．6％，男性患病率明显高于女性，差异有统计学意义（X2=4．140，P〈0．05）；HCMV感染327例，感染率为48．1％，男性188例感染率46．2％，女性139例感染率50．9％；男女感染率比较，差异无统计学意义；中度肥胖、血压异常、血脂异常和血糖异常病例HCMV感染率明显高于正常病例，差异均有统计学意义（P〈0．05）。结论石渠地区工作人员代谢综合征患病率较高，尤以中老年和男性人群为主；积极采取针对性预防措施，对减缓及控制MS、心脑血管疾病的发生具有重要作用。

OBJECTIVE To study the incidence of human cytomegalovirus （HCMV） infections in patients with metabolic syndrome and discuss the correlation between the HCMV infection and the metabolic syndrome so as to prevent stroke and related disease. METHODS From Jul to Oct, 2012, the physical examination data of 680 working staff who worked in Shiqu county that was 4100m above the sea level were analyzed, the subjects consisted of 407 male and 273 female, with the age between 16 and 58 years old; the blood, body mass index, blood pressure, fasting blood glucose, triglycerides, and high-density lipoprotein cholesterol were observed and statistically analyzed with the use of SPSS13.0 software, and the chi-square test was performed. RESULTS Of totally 680 working staff investigated, 253 cases had the metabolic syndrome with the prevalence rate of 37.2%, including 164 （40.3%） cases of males and 89 （32.6%） cases of females, the morbidity of the males was significantly higher than that of the female, the difference was statistically significant （X2 = 4. 140, P〈0.05）. The HCMV infection occurred in 327 cases with the infection rate of 48.1%, including 188 （46.2%） cases of males and 139 （50.9%） cases of females, the difference in the infection rate between the male and the female was not statistically significant. The incidence rate of the HCMV infections was significantly higher in the subjects with moderate obesity, abnormal blood pressure, abnormal lipids or abnormal blood glucose than in the normal subjects, the difference was statistically significant （P%0.05）. CONCLUSION The incidence of metabolic syndrome is high in the working staff of Shiqu area, especially the mid-aged and elderly patients as well as the females to take targeted prevention measures plays an important role in the prevention and control of incidence of metabolic syndrome and cerebrovascular diseases.