基层医院抗菌药物序贯治疗小儿肺炎的临床应用研究

Clinical application of sequential antibiotics therapy in treatment of neonatal pneumonia in grass-roots hospital

目的研究抗菌药物序贯治疗在小儿细菌性肺炎治疗的临床应用价值。方法 2012年1-12月收集186例肺炎患儿临床资料,将其随机分为观察组、对照组各93例,观察组采用序贯疗法,对照组采用持续静脉用药,运用SPSS16.0统计软件对研究数据进行统计分析,两组疗效及费用组间均值比较采用t检验分析。结果观察组咳嗽、气促、体温、啰音及血白细胞、C-反应蛋白恢复正常时间与对照组比较差异均无统计学意义;治疗有效率观察组为92.4%、对照组为89.2%;不良反应发生率观察组为2.2%、对照组为7.5%,两组比较差异有统计学意义(P<0.05);观察组平均住院时间(4.8±1.7)d较对照组(6.4±2.1)d短、平均住院费用(659.9±207.2)元较对照组(1032.5±243.8)元少。结论抗菌药物序贯疗法对小儿肺炎疗效良好、不良反应率低、经济;值得临床推广应用。

OBJECTIVE To investigate the application value of sequential antibiotics therapy in the treatment of bacterial pneumonia in the neonates of a grass-roots hospital. METHODS A total of 186 children with pneumonia who were treated from Jan. to Dec. 2012 were enrolled in the study and randomly divided into the observation group and the control group, with 93 cases in each, then the observation group was given the sequential antibiotics therapy, while the control group was treated with the continuous intravenous administration, the statistical analy- sis was performed with the use of SPSS16.0 software. RESULTS The difference in the cough, shortness of breath, body temperature, rales, WBC, or time of recovery of C-reactive protein between the observation group and the control group was not statistically significant; the effective rate of observation group was 92.4%, and the control group was 89.2% the incidence of adverse reactions was 2.2% in the observation group, 7.5% in the control group, the difference between the two groups was statistically significant （P〈0.05）; the average hospitalization duration of the observation group was （4.8±1. 7） days, shorter than （6.4 ±2. 1） days of the control group ; the median cost of hospitalization of the observation group was（659.9±207.2）yuan, less than（1032.5±243.8） yuan of the control group. CONCLUSION The sequential antibiotics therapy can achieve great therapeutic effect on treatment of pneumonia in the neonates, with the incidence of adverse reactions low; it is economical and worthy to be promoted in the hospital.