ORM DL3/GSDM B基因多态性与儿童支气管哮喘遗传易感性的 M eta分析

ORMDL3/GSDMB polymorphism and childhood asthma susceptibility： a Meta-analysis

目的 探讨ORMDL3/GSDMB基因（rs7216389）多态性与儿童支气管哮喘（哮喘）易感性的关系。方法 检索PubMed数据库、万方数据库、中国知网全文数据库、维普数据库、中国生物医学文献数据库发表的有关ORMDL3/GSDMB 基因多态性与儿童哮喘的病例对照研究的文献，OR值及95% CI为效应指标，采用固定或随机效应模型进行合并分析，并进行偏倚评估。应用Review manager5.0软件进行统计学处理。结果 共纳入文献6篇，包含哮喘病例3289例，对照3391例。与野生基因型 CC相比，TT合并的 OR值（95% CI）为1.86（1.58～2.20），TT＋TC合并的OR值（95% CI）为1.56（1.35～1.80），按人群进行分层分析，亚洲人群TT、TT＋TC的OR值（95% CI）分别为1.51（1.15～1.98）、1.50（1.15～1.96），欧洲人群 TT、TT ＋TC的 OR值（95% CI）分别为 2.11（1.71～2.61）、1.69（1.42～2.02）。结论 ORMDL3/GSDMB基因（rs7216389）多态性与儿童哮喘易感性相关，与欧洲人群相比，亚洲人群易感性相对较低。

Objective To investigate the relationship between ORMDL3/GSDMB polymorphism and genetic susceptibility to childhood asthma. Methods The electronic databases PubMed, Wanfang, China National Knowledge Infrastructure （CNKI）, Weipu, and China Biology Medicinedisc （CBM） were browsed for published case-control studies on investigating the association between ORMDL3/GSDMB polymorphism and genetic susceptibility to childhood asth- ma. Odds ratio（OR） and 95% confidence interval （95% CI） were used to investigate the strength of the association. Fixed or random effect models were selected for pooled OR calculation. Publication bias was assessed. All statistical analysis was conducted with Review Manager 5.0 software. Results Six case-control studies with a total of 3289 child- hood asthma cases and 3391 controls were included. For the homozygote TT and T allele carriers （ TT ＋ TC） ,the pooled ORs （95% CI） were 1.86 （ 1.58 - 2.20） and 1.56 （ 1.35 - 1.80） compared to the homozygous genotype （CC）. In the stratified analysis by ethnicity,the ORs （95% CI） of the T allele carriers and the homozygote TT were 1.50（ 1.15 - 1.96） and 1.51 （ 1.15 - 1.98 ） among Asians. While among European, the ORs （ 95 % CI） of the T allele carriers and thehomozygoteTFwerel.69（1.42-2.02） and2.11（1.71 -2.61）.Conclusions ORMDL3/GSDMBpolymorphism is overall associated with childhood asthma susceptibility. However, the susceptibility in the Asians is a little lower com- pared with that of the European populations, which suggest a possible role of ethnic differences in genetic backgrounds.