摘要
建立了一种测定烟用接装纸中18种邻苯二甲酸酯类（PAEs）化合物的液相色谱-串联质谱（LC-MS／MS）法。剪碎后的样品用水浸润，加入乙醇超声萃取，提取液过0．22μm有机相滤膜后进行LC—MS／MS分析。结果表明：①以甲醇-5mmol／L乙酸铵的乙酸水溶液（乙酸和水体积比1：1000）为流动相，流速0．4mL／min进行梯度洗脱，18种PAEs在9min内得到良好分离，采用多反应监测（MRM）模式进行定性和定量分析，方法快速可靠，线性范围为1～500ng／mL，定性检出限为0．01～1．85mg／kg（S／N=3）。②该方法用于检测烟用接装纸中18种PAEs，操作简单快捷，回收率在82．8％～111．6％之间，相对标准偏差（RSD）小于10％。
A method for determining 18 phthalate compounds in tipping paper was developed with liquid chromatography-tandem mass spectrometry （LC-MS/MS）. The samples were ultrasonically extracted with ethanol after soaking with water. Then the extract was analyzed with LC-MS/MS after passing through of an organic phase membrane filter of 0.22μm. The results showed that ： l） The targeted phthalate compounds could be well separated in 9 minutes with gradient elution by using methanol and 5 mmol/L ammonium acetate in acetic acid-water solution （1 ： 1000, V/V） as the mobile phase at a flow rate of 0.4 mL/min. Multiple reaction monitoring （MRM） mode was adopted for qualitative and quantitative analyses. This method was reliable with the linear range of 1-500 ng/mL and the qualitative detection limit of 0.01-1.85 mg/kg （S/N=3）. 2） With the recovery of 82.8%-111.6% and the relative standard deviation （RSD） of less than 10%, this method featured good reproducibility.
出处
《烟草科技》
EI
CAS
北大核心
2013年第12期31-35,共5页
Tobacco Science & Technology
