摘要
目的 :探讨胃癌不同TNM分期患者和不同分化患者血清可溶性CD4(SCD4)、可溶性CD8(SCD8)浓度的变化。方法 :采用酶联免疫吸附方法中的双抗体夹心法测定胃癌患者 (63例 )及正常对照 (36例 )、胃炎患者 (31例 )和癌前病变患者 (胃炎伴不典型增生 ,8例 )血清SCD4和SCD8浓度。结果 :血清SCD4和SCD8浓度随正常 -胃炎 -癌前病变-胃癌而逐级升高。血清SCD4、SCD8浓度与胃癌TNM分期和胃癌分化程度均不相关 (P >0 .0 5 )。结论 :血清SCD4和SCD8浓度的测定对探讨胃癌患者免疫状态的变化有一定意义。
Purpose: To investigate changes of soluble CD 4(SCD 4) and soluble CD 8(SCD 8) in patients with stomach neoplasm. The serum of sixty three patients with stomach neoplasm, thirty one patients with gastritis, eight patienis with dysplasia and thirty six controls were abtained in the study. The serum concentrations of SCD 4 and SCD 8 were measured by enzyme link immunosorbent assay. Serum leyels of SCD 4 and SCD 8 increased from normal controls to gastritis group to dysplasia group to cancer group. Serum levels of SCD 4 and SCD 8 correlated with neither the TNM stage nor the degree of differentiation of stomach neoplasm (P>0.05). SCD 4 and SCD 8 are valuable markers to discover the immunechanges in patienis with stomach neoplasm.
出处
《临床消化病杂志》
2000年第6期248-250,共3页
Chinese Journal of Clinical Gastroenterology
