自发性细菌性腹膜炎病人腹水G-CSF和CRP检测的临床意义

The Clinical Significance of Measurement of G-CSF and CRP in Ascites of Spontaneous Bacterial Peritonitis

目的 :探讨自发性细菌性腹膜炎 (SBP)病人腹水中粒细胞集落刺激因子 (G CSF)和C 反应蛋白 (CRP)水平的变化和临床意义。方法 :采用双抗体夹心ELISA法测定G CSF ,快速免疫消浊比浊法测定CRP。结果 :2 8例SBP病人血清和腹水G CSF和CRP水平明显高于 2 0例漏出性腹水病人 (P <0 .0 1)。SBP病人腹水中的G CSF和CRP水平明显高于血清中的水平。随着感染的控制 ,腹水中G CSF和CRP水平逐渐下降 (P <0 .0 5 )。结论 :腹水G CSF和CRP的检测有助于对SBP的诊断和疗效观察。

Purpose: To studied the clinical significance of levels of granulocyte colony stimulating factor(G CSF) and C reactive protein(CRP) in ascites of spontaneous bacterial peritonitis(SBP) cases. Methods: G CSF and CRP levels in 28 patients with SBP and 20 patients wiht transudate. Results: G CSF and CRP levels in serum and ascites were higher in SBP patients ascites than that with transudate patients (P<0.01). G CSF and CRP levels in ascties were higher than that in serum. With the control of SBP,the ascites level of G CSF and CRP decreased(P<0.01). Conclusions: Measurement of G CSF and CRP in ascites is helpful for physician to diagnose SBP and to observe treatment effects.