禽类生殖系统非特异性免疫反应的研究进展

Research Progress in Avian Innate Immune Response of Reproductive Organs

禽类卵巢和输卵管易受病原微生物侵害,引起生殖功能异常和鲜蛋污染,威胁生殖健康和蛋源食品安全。卵巢和输卵管存在抵御病原微生物侵染的非特异性免疫反应,维持生殖功能稳定。本文综述了国内外禽类卵巢和输卵管非特异性免疫反应关键调控因子前炎性细胞因子、趋化因子、Toll样受体和禽类β-防御素的最新研究进展。

The avian ovary and oviduct are predilection sites for pathogenic microorganisms, which may lead to reproductive functional disorder and production of contaminated eggs, and subsequently impair reproductive health and egg-sourced food safety. The innate immune function of the ovary and oviduct is essential to protect the reproductive organs form infection as well as for production of hygienic eggs, and to maintain the normal functions of the ovary and oviduct. This paper reviewed the newest advances in the key mediators of the avian innate immune response, such as proinflammatory cytokines, chemokines, Toll-like receptors and avian β- defensins.