中药复方对肺心病肺动脉高压患者血管内皮功能的影响

Traditional Chinese Medicine Compound Effects on Lung Vascular Endothelial Function in Patients with Pulmonary Arterial Hypertension

目的:探讨中药复方对肺心病肺动脉压的影响因素及发生演变机制。方法:随机纳入240例慢性肺源性心脏病气虚血瘀兼痰阻的患者,分为治疗组、对照组各120例,对照组在常规治疗的基础上联合硝苯地平口服,治疗组在对照组治疗基础上予中药复方中药复方日一剂口服,疗程2周,以ET-1、NO、血液流变学为观察指标。结果:经t检验统计分析,肺动脉压、全血高切黏度、全血低切黏度治疗组对照组改善,差异具有统计学意义(P<0.05),ET-1、NO、红细胞压积治疗组较对照组改善明显,差异具有统计学意义(P<0.01)。经多元相关分析ET-1与肺动脉压之间存在正相关关系,NO与肺动脉压之间存在负相关关系。结论:中药复方有助于肺心病患者肺动脉高压的缓解,其机制可能与保护肺血管内皮细胞、重建血管活性因子平衡,改善血流变学等有关。

Objective ： To study the factors and mechanisms of the Chinese herbal compound affecting on pulmonary heart dis ease （PHD）. Methods ：240 chronic PHD patients whose pattern of syndrome was Qi deficiency and blood stasis combining phlegm resistance were selected into the study and randomly divided into treatment group （120 cases） and control group （120 cases ）. Control group received Nifedipine orally based on the routine treatment, and treatment group received Chinese herbal compound a dose orally once a day based on the control ~roup~ treatment, Each arouo was treated for two weeks. The ET 1. NO and hemorheology were observed. Results：Compared with the control group by using T test statistic analysis, treatment group＇s pulmonary artery pressure （PAP）, whole blood low shear viscosity, whole blood high shear viscosity were improved （P 〈 0.05 ）. The ET 1, NO and HCT were significantly improved（P 〈 0. 01 ）. The multiple correlation analysis showed that there was positive correlation be tween the ET 1 and PAP, and negative correlation between the NO and PAP. Conclusion： Chinese herbal compound was contrib ute to reduce the PAP in PHD patients, and its mechanism may be associated with the protection of pulmonary vascular endothelial cells, reconstruction of the vessel activating cytokine balance,and improvement of hemorheology and etc.