痰热清注射液联合沙美特罗氟替卡松粉吸入剂对放射性肺炎患者的临床分析

Clinical Analysis on Effects of Tanreqing Injection Combined with Salmeterol and Fluticasone Propionate Powder for Inhalation in Treatment of Radioactive Pneumonia

目的:对痰热清注射液联合沙美特罗氟替卡松粉吸入剂治疗放射性肺炎的临床效果和安全性进行观察和分析。方法:将选取60例放射性肺炎患者作为研究对象,随机分为观察组和对照组,每组各30例,对照组患者在常规疗法的基础上给予沙美特罗氟替卡松粉吸入剂治疗,观察组患者在对照组疗法的基础上加用痰热清注射液。对两组患者的治疗效果、常见症状改善时间、治疗前、后的KPS评分和不良反应进行观察和分析。结果:观察组和对照组的显效率分别为76.7%和46.7%,观察组的显效率显著高于对照组(P<0.05);两组的临床有效率分别为100%和86.7%,观察组的临床有效率显著高于对照组(P<0.05);观察组在退热、止喘、止咳、胸痛消失、痰颜色变化、肺啰音消失和X线平片阴影消失的改善时间方面均显著短于对照组(P<0.05);两组患者的KPS评分均较治疗前有了显著提高(P<0.05),且观察组患者治疗后KPS评分改善程度大于对照组(P<0.05);两组不良反应发生率的差异无显著性(P>0.05),且均未见严重的不良反应。结论:痰热清注射液联合沙美特罗氟替卡松粉吸入剂治疗放射性肺炎的效率更好、症状改善更快,且安全性较高,值得在临床上推广应用。

Objective ：To observe and analyze the effects and safety of Tanreqing Injection combined with salmeterol and fluti casone propionate powder for inhalation in the treatment of the patients with radioactive pneumonia. Methods ：60 cases of radiation pneumonia patients were selected as research objects and randomly divided into the observation group and the control group. 30 cases were included into each group. The patients in the control group were treated with salmeterol and fluticasone propionate pow der for inhalation on the basis of the conventional therapy,while the patients in the observation group combined Tanreqing injec tion on the basis of the therapy of the control group. The curative effects, the time for symptoms to improve, the KPS scores before and after the treatment and the adverse reactions of the patients in the two groups were observed and analyzed. Results ： The signifi cant effective rates in the observation group and the control group were 76.7% and 46.7% respectively,and the significant effec tive rate of the observation group was significantly higher than that of the control group（P 〈0. 05）. The clinical effective rates in two groups were 100% and 86.7%, and the clinical effective rate of the observation group was significantly higher than that of the control group （ P 〈 0. 05 ）. The improving time for fever decreasing, asthma stopping, cough stopping, chest pain disappearing, spu tum color changing, and pulmonary X ray film shadow disappearing of the observation group was significantly shorter than those in the control group （P 〈 0. 05 ）. The KPS scores of the patients in the two groups were increased significantly compared with those before treatment （ P 〈 0. 05 ）, and the KPS score improvement of the patients in the observation group after treatment was greater than that in the control group （ P 〈 0. 05）. There was no significant difference of the incidence of adverse reactions be tween the two groups （P 〉 0. 05 ） and no serious adverse reactions were observed. Conclusion ： The application of Tanreqing Injec tion combined with salmeterol and fluticasone propionate powder for inhalation in the treatment of radioactive pneumonia is more efficient. The symptoms improve faster and the security is high. The treatment is worthy of clinical application.