中药浴足方对血压晨峰的影响

Effect of Chinese Herbs Foot-bath Recipe on Morning Blood Pressure Surge

目的：评价中药浴足方对轻中度原发性高血压患者血压晨峰程度的影响。方法：采用随机、对照试验设计，纳入轻中度原发性高血压患者124例，随机分为常规降压组（对照组，n=60）和常规＋中药浴足组（中药浴足组，n=64）。常规组口服氨氯地平片5mg联合厄贝沙坦片150mg，1〉L／天；中药浴足组在常规组治疗的基础上加用中药浴足，疗程为10天。应用动态血压评价两组患者24h平均血压、服药后18—24h平均血压和血压晨峰程度的变化。结果：治疗10天后，两组患者24h平均SBP／DBP均有降低，与治疗前比均有明显差异（P〈0．05），但组间对比无差异（P〉0．05）；治疗后两组服药后18—24h平均血压均明显下降，中药浴足组SBP／DBP下降幅度（17．8±9．0）／（10．2±3．0）mmHg，组间对比有明显差异（P〈0．05）；此外，中药浴足组血压晨峰程度下降（6．4±4．0）／（4．8±2．5）mmHg，与常规降压组比较有统计学差异（P〈0．05）。结论：在联合常规降压治疗的基础上加用中药浴足方，不但24h降压达标，而且更能有效控制血压晨峰程度，提高降压质量。

Objective ：To evaluate the effect of Chinese herbs foot bath recipe on morning blood pressure surge in nfild and moderate essential hypertension. Methods ： In this randomized, controlled trial, 124 hypertensive patients in hospital were enrolled and divided into two groups,including control group （n =60） received 5 mg Amlodipine tablet and 150 mg Irbesartan tablet once a day and Chinese herbs foot bath recipe group （ n = 64） administrated the routine antihypertensive therapy with Chinese medicine foot bath for 10 days. All participants were assessed the level in blood pressure at baseline and endpoint using ABPM. Re sults ：After treatment for 10 days,24 h SBP/DBP in two groups was decreased, compared with the baseline （P 〈 0. 05）, the com parisons between groups were not significant（ P 〉 0. 05 ）. The 18 24 h SBP/DBP after administration in foot bath group was re duced by （ 17.8 ±9.0）/（ 10. 2 ±3.0） mmHg,compared with the reduction of control group there was significant difference （P 〈 0. 05 ）. In addition, the extent of MBPS in foot bath group was reduced by （6.4± 4. 0） / （4. 8± 2. 5 ） mmHg and was signifi cantly more than that of control group, showing inter groups differences （ P 〈 0. 05 ）. Conclusion ： Chinese herbs foot bath recipe combined the routine antihypertension effectively reduced the 24 h blood pressure of mild or moderate essential hypertension and attenuated the extent of MBPS to improve the quality of controlling hypertension.