急性冠状动脉综合征中C反应蛋白的临床意义及阿司匹林的作用

The Clinical Significance of C-Reactive Protein in Patients with Acute Coronary Artery Syndrome and the Effect of Aspirin on It

为探讨C反应蛋白与急性冠状动脉综合征的关系及阿司匹林对其的影响 ,观察 46例急性心肌梗死患者、40例不稳定性心绞痛患者及 42例稳定性心绞痛患者的C反应蛋白浓度以及不同剂量的阿司匹林对心肌梗死患者C反应蛋白浓度的影响。结果发现心肌梗死及不稳定性心绞痛患者的C反应蛋白浓度较稳定性心绞痛患者显著增高 (P <0 .0 0 1)。小剂量 (每天 30 0mg)阿司匹林可降低心肌梗死患者的C反应蛋白浓度 (P <0 .0 5 )。提示C反应蛋白浓度可作为评价急性冠状动脉综合征患者预后的一个参考指标。

Aim To study the association between C-reactive protein(CPR) and acute coronary artery syndrome. Methods CRP concentration were examined in 46 patients with acute myocardial infarction, 40 patients with unstable angina and 42 patients with stable angina. The effect of different dosages of aspirin on CRP concentration of acute myocardial infarction patients. Results CRP concentration in patients with acute myocardial infarction and unstable angina were significantly higher than that of patients with stable angina (P<0.001). CRP concentration in patients with acute myocardial infarction could be reduced with 300 mg/d dosage of aspirin (P<0.05). Conclusion CRP concentration as a prognostic marker may be useful in the evaluation of acute coronary artery syndrome