铂类药物的不良反应及其防治

Adverse reactions, prevention and treatment of platinum compounds

铂类药物是目前临床应用最广泛的抗肿瘤药物类别之一,但因存在不同类型和程度的不良反应,故预防和降低不良反应的发生对提高患者的生活质量和减少额外的治疗费用具有重要意义。本文综述铂类药物的各种不良反应的发生机制及其防治方法,以期为使用铂类药物进行个体化治疗提供参考。

Platinum compounds is one of the most widely used anti-tumor drugs for many types of malignant tumors. However, in view of different types and levels of adverse reactions, it is vital to prevent and reduce the occurrence of these adverse reactions so as to improve the quality of life and lower the extra cost of their treatment. The mechanism, prevention and treatment of various platinum-associated adverse reactions are reviewed so that a certain guide can be provided for the individualization of platinum-based therapy.