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SHIP及其相关信号通路与炎症性肠病 被引量：1

Correlation of SHIP and Related Signaling Pathways with Inflammatory Bowel Disease
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摘要 人类SHIP蛋白为肌醇磷酸酶家族成员之一,由定位于染色体2q37.1的INPP5D基因编码,主要表达于造血细胞中,在造血细胞的生长、分化和功能发挥方面起关键性负向调控作用。PI3K信号通路对免疫系统功能的调控具有重要意义。SHIP能特异性地水解PI3K的第二信使PI-3,4,5-P3(PIP3)肌醇环上的5’位磷酸,生成PI-3,4-P2,从而下调PI3K依赖性Akt激活,负向调控PI3K-Akt信号通路。目前对SHIP在包括炎症性肠病(IBD)在内的自身免疫性和炎症性疾病中的表达及其意义仍处于探索阶段,尚未形成系统性认识。本文就SHIP及其相关信号通路与IBD的关系作一综述。 Human SHIP protein belongs to the family of inositol phosphatases and is encoded by the INPP5D gene on chromosome 2q37. 1. SHIP is hematopoietic-restricted expressed and exerts a pivotal role in negatively regulating the growth, differentiation and function of hematopoietic cells. PI3K mediated signaling pathway is critical for the normal function of immune system. SHIP specifically hydrolyzes PI-3,4,5-P3 （PIP3） , the seeond messenger of PI3K signaling, removing the phosphate from the 5＇-position of inositol ring to generate PI-3,4-P2, thereby down-regulating the PI3K- dependent activation of Akt and negatively regulating the PI3K-Akt signaling pathway. However, expression and significance of SHIP in autoimmune and inflammatory diseases including inflammatory bowel disease （ IBD ） has not yet been clear and is still in the proeess of elucidation. This article reviewed the correlation of SHIP and related signaling pathways with IBD.
作者 蒋巍亮 郑萍
机构地区 上海交通大学附属第一人民医院消化科 同济大学附属东方医院消化医学部
出处 《胃肠病学》 2013年第11期686-689,共4页 Chinese Journal of Gastroenterology
关键词 炎症性肠病 SHIP 磷脂酰肌醇3-激酶类 信号传导 巨噬细胞 内毒素耐受 Inflammatory Bowel Disease SHIP Phosphatidylinositol 3-Kinases Signal Transduction Maerophages Endotoxin Tolerance
分类号 R574 [医药卫生—消化系统]
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参考文献24

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共引文献1

同被引文献34

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胃肠病学
2013年 第11期

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