老年BPH与代谢综合征关系的临床研究

Clinical study of correlation between BPH and metabolic syndrome in elderly

目的:探讨代谢综合征与BPH的相关性。方法:将伴有下尿路症状的246例老年BPH患者根据有无代谢综合征分成两组:Ⅰ组伴有代谢综合征患者139例,Ⅱ组不伴代谢综合征患者107例,测量体质指数(BMI)、血压、腰围,根据下尿路症状进行国际前列腺症状评分(IPSS)。所有患者检查空腹血糖(FBG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、空腹胰岛素水平(FINS)、糖化血红白水平(HbA1c)、餐后血糖(PBG)及前列腺特异抗原(PSA),计算胰岛素抵抗指数(HOMA-IR)。经腹部超声测量前列腺三径计算前列腺体积(PV)。结果:老年BPH患者高血压、冠心病、糖尿病的患病率高,代谢综合征组患者BMI、SBP、FBG、PBG、LDL-C、TG、FINS、HbA1c及PV较对照组显著升高,且存在胰岛素抵抗,差异具有统计学意义(P<0.05)。结论:老年BPH患者存在胰岛素抵抗,研究表明代谢综合征可能促进BPH。因此,改善胰岛素抵抗可能对预防BPH有一定作用。

Objective：To investigate the correlation between metabolic syndrome and benign prostatic hyperpla- sia （BPH）. Method：Two hundred and forty-six BPH patients with lower urinary symptoms were divided into two groups according to whether they had metabolic syndrome. There were 139 cases with metabolic syndrome in group Ⅰ while 107 cases without metabolic syndrome in group Ⅱ. Blood pressure, the body mass index （BMI） and waist circumference were measured. All the patients were evaluated by International Prostate Symptom Score （IPSS）. Biochemical analyses including fasting blood glucose （FBG）, two hours postprandial blood glucose （PBG）, high-density lipoprotein cholesterol （HDL-C）, low-density lipoprotein cholesterol （LDL-C）, triglycerides （TG）, fasting insulin （FINS）, glycated hemoglobin （HbAlc） and prostate-specific antigen （PSA） were measured and insulin resistance （HOMA-IR） were calculated. Prostate volume （PV） was measured by abdominal ultra- sound. Result：Elderly with BPH had higher incidence of hypertension, diabetes, as well as coronary artery dis- ease. The indices of BMI, SBP, FBG, PBG, LDL-C, TG, FINS, HbAlc and PV were significantly higher in metabolic syndrome group. There were significant differences between the two groups （P〈0.05）. Conclusion：The present study demonstrates that insulin resistance can be seen in elderly with BPH. The metabolic syndrome may contribute to the development of BPH. Thus, decreasing insulin resistance may prevent the occurrence of BPH.