摘要
抗肿瘤药物是目前治疗肿瘤最主要的方法,但肿瘤对药物的反应往往很短暂,且不可避免的出现抗药,使其成为攻克肿瘤最大的难题之一。目前对于肿瘤抗药的分子机制并不十分清楚,除了传统观点强调的基因突变,近年来越来越多的研究揭示了表观遗传学调控在肿瘤抗药中的作用,深入分析表观修饰对药物抗性的影响,不仅可以为肿瘤对药物的反应提供敏感的早期检测,更为肿瘤个体化治疗提供更有效的治疗靶点。
Anti-tumor drug remains the primary treatment for most disseminated cancers. However, the response to anti-tumor drug is often transient, and development of resistance is one of the most significant obstacles to effective cancer therapy. The molecular mechanisms underlying cancer resistance are only partially understood. In addition to genetic changes, reversible transcriptional states controlled by epigenetic are believed to play a role in generating dynamic drug-resistance. These observations have important clinical consequences as they provide an opportunity for exploring a more efficient epigenetic therapy as well as potential biomarkers mediating non-invasive monitoring.
出处
《基础医学与临床》
CSCD
北大核心
2013年第12期1638-1641,共4页
Basic and Clinical Medicine
基金
长江学者和创新团队发展计划(IRT1052)
