摘要
基因组不稳定性是胃癌的重要特征之一,随着基因组研究技术的进步,愈来愈多的证据表明基因组不稳定在慢性萎缩性胃炎、胃溃疡、不典型增生及肠上皮化生到胃癌这一动态发展过程中起着至关重要的作用,相关研究为胃癌的早期诊断、个性化防治和预后评价提供了新思路。
Gastric carcinoma is characterized by genomic instability, researches show that genomic instability play significant roles in the pathological process of chronic atrophic gastritis, gastric ulcer, atypical hyperplasia, intestinal metaplasia and gastric carcinoma. Above all, relevant researches will create a new guidance for the early diagnosis, immunotherapy and prognostic evaluation of gastric cancer.
出处
《基础医学与临床》
CSCD
北大核心
2013年第12期1642-1645,共4页
Basic and Clinical Medicine
关键词
基因组不稳定
微卫星不稳定
染色体不稳定
胃癌
癌前病变
genomic instability
microsatellite instability
chromosomal instability
gastric carcinoma
precancerous lesions
