微米级羰基铁粉磁性骨水泥的制备与表征

Preparation and characterization of polymethylmethacrylate-based magnetic bone cements containing micron carbonyl iron powder

背景:目前有日本学者提出采用磁性骨水泥治疗肿瘤的骨转移,然而现行磁性骨水泥添加的均为纳米级磁流体,将微米级羰基铁粉添入骨水泥的研究尚未见报道。目的:制备含不同比例微米级羰基铁粉的磁性骨水泥,并按ISO 5833标准测量相关指标及其磁性与体外升温情况。方法:将微米级羰基铁粉与聚甲基丙烯酸甲酯骨水泥混合制备成含羰基铁粉质量分数分别为0%,20%,30%,40%,50%的磁性骨水泥。将以上5组材料按ISO 5833标准测定凝固时间、聚合温度、抗压强度。并采用振动样品磁强计测定各组磁性及在交变磁场下的升温情况。结果与结论:随着羰基铁粉含量的增加,磁性聚甲基丙烯酸甲酯骨水泥的凝固时间有所延长。各组骨水泥的最高聚合温度均在65-70℃之间,并未随羰基铁粉含量的增加而改变,仅聚合温度最高点出现的时间随羰基铁粉含量提高而后延。各组骨水泥的抗压能力均大于60 MPa,但只有聚甲基丙烯酸甲酯骨水泥的抗压能力>70 MPa,符合IOS 5833标准要求。各组磁性骨水泥的磁饱和强度随羰基铁粉含量的提高而提高。在交变磁场下,磁性骨水泥的升温速率与磁场强度和羰基铁粉含量呈正相关。

BACKGROUND： Magnetic bone cements have been used to treat bone metastasis in Japan, which are made by adding Fe3O4nanoparticles to bone cements. Magnetic bone cements containing micron carbonyl iron powder have not been reported.OBJECTIVE： To prepare polymethylmethacrylate-based cements containing carbonyl iron powder, and to test the magnetic characterizations and the heat-generating abilities of all samples according to ISO 5833 standard in vitro.METHODS： The carbonyl iron powder was mixed with polymethylmethacrylate-based bone cement power to prepare magnetic bone cements containing 0%, 20%, 30%, 40%, and 50% carbonyl iron powder, respectively.The setting time, polymerization temperature, compressive strength, magnetic property and in vitro heat-generating ability were tested.RESULTS AND CONCLUSION： The setting time and polymerization temperature were increased with the increased content of carbonyl iron powder. The highest polymerization temperature of each sample was65-70 ℃. The increased content of carbonyl iron power could not change the highest polymerization temperature but delay its appearance. The compressive strength of each sample was higher than 60 MPa, and moreover, the compressive strength of the pure polymethylmethacrylate-based bone cement was higher than 60 MPa, which met the ISO 5833 standard. The saturation magnetic intensity was increased with the increasing of carbonyl ironpower content. The heat-generating ability of magnetic bone cements had a positive correlation with the magnetic field strength and the content of carbonyl iron powder.