足细胞蛋白Nephrin、Podocin与肾小球疾病

Podocyte protein nephrin、podocin and glomerulopathy

肾小球疾病是指累及两侧肾小球的一类疾病,多以蛋白尿为主要临床表现,由于发病机理尚不明确,因此疾病早期缺乏准确有效的检测和诊断手段。近来研究发现足细胞蛋白Nephrin和Podocin在多种肾小球疾病发生发展和诊断预测中起重要作用。本文就近几年Nephrin、Podocin与肾小球疾病的相关研究进行综述。

Glomerulopathy is one class of disease mostly relate to both sides of glomerulus and take proteinuria as main clinical manifestations, as its pathogenesis is not clear, so the accurate and effective detection and diagnostic method is still absenced. Recent studies have found podocyte proteins Nephrin and Podocin play critical role in the development, diagnose and forecast of numerous glomerular diseases. In this paper, we review the research of Nephrin and Podocin in the Glomerulopathy recently.