复方南星止痛膏联合双醋瑞因治疗膝骨关节炎临床研究

Clinical Observation on Knee Osteoarthritis Treated with Nanxing Compound Analgesic Paste and Diacerein

目的:观察复方南星止痛膏联合双醋瑞因治疗膝骨性关节炎的临床疗效。方法:将60例患者随机分为2组,治疗组采用复方南星止痛膏联合双醋瑞因治疗,对照组采用双醋瑞因联合辣椒碱软膏治疗,均治疗14d为1个疗程。结果:两组在治疗后14d,膝关节VAS指数明显下降;WOMAC关节炎评估疼痛、僵硬、功能活动积分明显下降。与治疗前相比差异均有统计学意义(P<0.05),两组治疗后VAS指数、WOMAC疼痛、僵硬、功能障碍积分比较差异有统计学意义(P<0.05)。结论:复方南星止痛膏联合双醋瑞因治疗膝骨性关节炎疗效显著,安全性高,不良反应少;复方南星止痛联合双醋瑞因疗效优于双醋瑞因联合辣椒碱软膏。值得临床推广应用。

Objective：To observe the clinical effect of Nanxing compound analgesic paste and diacerein on knee osteoarthritis. Methods： All 60 patients of knee osteoarthritis were randomly divided into two groups with 14 days treatment. The treatment group were treated with Nanxing compound analgesic paste and diacerein, while control group with diacerein and capsaicin ointment. Results：At the end of treatment, the knee joint VAS index, WOMAC arthritis scores in pain, stiffness and functional movement of both groups obviously decreased （P〈0.05, P〈0.01）. Conclusion： The combined treatment of Nanxing compound analgesic paste and diacerein is effective, safe and better than the combined treatment of capsaicin ointment and diacerein on knee osteoarthritis with less adverse reaction.