透明质酸钠在真菌性角膜溃疡治疗中的作用

Effect of sodium hyaluronate in treating fungal corneal ulcer

目的:回顾性分析透明质酸钠在真菌性角膜溃疡治疗中的效果。方法:2006-06以来,在我院接受药物治疗的真菌性角膜溃疡患者共178例178眼,其中2006-06/2008-06期间共81例81眼作为对照组,接受以那他霉素及氟康唑为主的传统抗真菌方案治疗;2008-06/2010-03期间97例97眼作为治疗组,在传统治疗方案基础上加用透明质酸钠治疗。对比分析两种治疗方法的效果。结果:治疗组97例,平均住院时间14.15±4.23d,治愈90例,治愈率92.8%,好转5例,占5.2%,无效2例,占2.1%,最终视力>0.3者占51.6%。对照组81例,平均住院时间17.26±6.23d,治愈69例,治愈率85.2%,好转7例,占8.6%,无效5例,占6.2%,最终视力>0.3者占39.5%。经统计学分析,两组的平均住院时间、治愈率、有效率及最终视力差异具有统计学意义(P<0.05),治疗组的平均住院时间短于对照组,治愈率及有效率高于对照组,最终视力好于对照组。结论:透明质酸钠可促进真菌性角膜溃疡愈合,提高治愈率,减少角膜瘢痕形成。

METHODS： Since June, 2006, there were 178 patients （ 178 eyes ） with fungal corneal ulcer receiving medical treatment in our hospital.Among them, 81 patients （ 81 eyes ） as the control group received the traditional antifungal treatment with the natamycin and fluconazole being the major medicine, from June 2006 to June 2008. While, 97 patients （ 97 eyes ） as the treatment group received sodium hyaluronate treatment based on traditional antifungal treatment during the period of June 2008 to March 2010.Effects of two therapeutic methods were compared and analyzed. RESULTS： Of the 97 cases in the treatment group, the average hospital stay was： 14.15 ±4.23d, with 90 cases （ 92.8%） cured, 5 cases （ 5.2%） improved, 2 cases （ 2.1%） ineffective, the final visual acuity of 51.6%patients better than 0.3.Of the 81 cases in the control group, average hospital stay was： 17.26 ±6.23d, with 69 cases （85.2%） cured, 7 cases （8.6%） improved, 5 cases （6.2%） ineffective, the final visual acuity of 39.5%patients better than 0.3. After statistical analysis, the average hospital stay, the cure rate, the effective rate and the final visual acuity in both groups showed statistically significant difference （P〈0.05）.The average hospital stay of the treatment group was shorter than that of the control group, while the cure rate and effective rate and the final visual acuity was better than that of the control group. CONCLUSION：Sodium hyaluronate can promote fungal corneal ulcer healing, improve the cure rate and reduce the formation of corneal scar.