血清及房水中IL-6水平与炎症性青光眼的相关性研究

Study of the correlation between inflammatory glaucoma and IL-6 levels in serum and aqueous humor

目的:测定炎症相关性青光眼(简称炎症性青光眼)患者血清及房水中白细胞介素-6(IL-6)的水平,探讨IL-6在炎症性青光眼发生发展中的作用。方法:选取炎症性青光眼患者20例20眼作为试验组(A组),原发性慢性青光眼(原发性慢性开角型青光眼和原发性慢性闭角型青光眼)患者20例20眼作为高眼压对照组(B组),老年性白内障患者20例20眼作为正常对照组(C组)。采集三组患者血清及房水标本,通过电化学发光法分别检测血清与房水中IL-6的水平。结果:炎症性青光眼组、原发性慢性青光眼组、老年性白内障组血清IL-6水平分别为3.26±2.10,4.20±1.94,3.50±2.24pg/mL,差异无统计学意义(F=1.080,P=0.345)。炎症性青光眼组、原发性慢性青光眼组、老年性白内障组房水IL-6水平分别为293.77±38.72,135.27±32.72,115.80±29.97pg/mL,差异有统计学意义(F=164.86,P=0.000),炎症性青光眼组明显高于原发性慢性青光眼及老年性白内障组,差异有统计学意义(P<0.01;P<0.01),原发性慢性青光眼组与老年性白内障组相比,差异无统计学意义(P>0.05)。结论:炎症性青光眼患者房水IL-6水平的高表达与炎症反应密切相关,与高眼压状态无明显相关性。

AIM：To discuss the role of interleukin-6 （ IL-6 ） in the development of inflammatory glaucoma by detecting the IL-6 levels in serum and aqueous humor of inflammatory glaucoma patients. METHODS： Totally 20 patients （ 20 eyes ） with inflammatory glaucoma were selected as experimental group, 20 patients （ 20 eyes ） with primary chronic glaucoma （ primary chronic angle-closure glaucoma and primary chronic open angle glaucoma ） as the high intraocular pressure control group, and 20 senile cataract patients （ 20 eyes ） as the normal control group.Three specimens of serum, aqueous humor in three groups were collected and aqueous IL-6 levels were measured through electrochemiluminescence. RESULTS： The serum IL -6 levels in Inflammatory glaucoma group, primary chronic glaucoma group, senile cataract group were 3.26±2.10, 4.20±1.94 and 3.50 ±2.24pg/mL, respectively, which doesn＇t demonstrate statistically significant differences （F=1.080, P=0.345）. The aqueous IL-6 levels in the Inflammatory glaucoma group, primary chronic glaucoma group and senile cataract group aqueous were 293.77±38.72, 135.27±32.72 and 115.80 ± 29. 97pg/mL, respectively, demonstrating statistically significant differences （F=164.86, P=0.000）. The Inflammatory glaucoma group was found to be significantly higher than that in the primary chronic glaucoma and senile cataract group （P〈0.01; P〈0.01）. Comparing the aqueous IL-6 levels in the primary chronic glaucoma group with that in the senile cataract group, the differences of it were not statistically significant （P〉0.05）. CONCLUSION： High expression of IL -6 levels in aqueous humor of inflammatory glaucoma patients is closely associated with inflammation, but it has no significant correlation with high intraocular pressure.