三维适形放疗联合替吉奥治疗老年食管癌患者的临床研究

Clinical study of S-1 combined with three-dimensional conformal radiotherapy for elderly patients with esophageal cancer

目的:探讨替吉奥联合三维适形放疗治疗老年食管癌患者的临床疗效。方法:76例老年食管癌患者随机分为替吉奥联合放疗组(38例)和单独放疗组(38例)。两组均采用三维适形放疗,联合组在放疗同期行替吉奥单药化疗,60mg/(m2·d),同时给予一定的对症支持治疗。治疗前后行上消化道造影、胸部CT等检查,以评价疗效。结果:联合组总有效率为89.5%,单放组总有效率为68.4%,差异具有统计学意义(P<0.05)。两组主要毒副反应为食管炎、血液学毒性,患者均可耐受。结论:三维适形放疗联合替吉奥治疗老年食管癌患者,疗效较好,不良反应可以耐受,值得进一步推广应用。

Objective：To investigate the clinical effects of S - 1 combined with three - dimensional conformal ra- diotherapy （3DCRT） for elderly patients with esophageal cancer. Methods：A total of 76 elderly patients with esopha- geal cancer were randomly divided into chemoradiotherapy group （S1 combined with 3DCRT, n = 36） and radiothera- py alone group（ n = 36）. 3DCRT was adopted in the two groups. Patients in chemoradiotherapy group received S - 1 60mg/（ m2 · d） concurrent with 3DCRT. Upper digestive tract radiograph, chest CT were performed before and after the treatment. Results：In chemoradiotherapy and radiotherapy alone groups, the total effective rates （CR ＋ PR） were 89.5% and 68.4% ,respectively. There was significant difference between two gronps（P 〈 0.05 ）. The main adverse effects were esophagitis and hematological toxicities. Conclusion：S - 1 combined with 3DCRT for elderly patients with esophageal cancer is effective and tolerable.