血清NSE与非手术的非小细胞肺癌预后及治疗的关系

Relationship between serum NSE and therapeutic effect and prognostic in inoperable non-small-cell lung carcinoma

目的:探讨血清神经元特异烯醇化酶(NSE)、癌胚抗原(CEA)水平与非手术的非小细胞肺癌疗效及预后的关系。方法:收集非手术的非小细胞肺癌患者血清38例,肺部良性病变患者血清26例。电化学发光免疫分析仪测定CEA和NSE水平。各组NSE、CEA水平用秩和检验进行比较,Logistic回归分析评估NSE、CEA水平与治疗效果的关系。结果:CEA水平在鳞癌组与腺癌组有显著差异,P<0.001。NSE水平在鳞癌组与肺良性病变组间有显著性差异,P<0.005。腺癌与肺良性病变组比较,CEA与NSE水平均有统计学差异,分别P<0.005和P<0.05。化疗前后NSE、CEA水平无统计学差异。NSE>15.2ng/ml与疗效有统计学差异,P<0.05。结论:血清NSE在非手术的非小细胞肺癌与肺部良性病变的鉴别诊断中有一定的意义,血清水平NSE>15.2ng/ml的非手术的非小细胞肺癌患者疗效差的可能性大于NSE≤15.2ng/ml患者。

Objective：To study the relationship between serum NSE and CEA concentration and therapeutic effect and prognostic in inoperable non - small cell lung cancer （NSCLC）. Methods：All 38 cases of inoperable non - small -cell lung carcinoma and 26 benign lung diseaes were collected. Electrochemiluminescence immunoassay analyzer was used to detect CEA and NSE levels. Using the Wilcoxon rank sum test to compare NSE and CEA levels. Logistic regression analysis was used to assess the relationship between NSE and CEA level and therapeutic effect. Results： CEA concentration in squamous cell carcinoma and adenocarcinoma group showed significant differences,P 〈 0.001; NSE concentration between squamous cell carcinoma and benign lung lesions was significantly different,P 〈 0.005. In ad- enocarcinoma and benign lung lesions groups, CEA and NSE concentrations were significantly different, P 〈 0.05 ; before and after chemotherapy, NSE and CEA concentration were not significantly different;there were significant differences between NSE 〉 15.2ng/ml and efficacy（P 〈 0.05 ）. Conclusion：Serum NSE concentration has a certain sense in differential diagnosis between NSCLC and benign lung disease. The possibility of poor efficacy in patients with levels of NSE 〉 15.2ng/ml was greater than the patients with levels of NSE ≤15.2ng/ml.