Ki-67在人肝癌组织中的表达特点

Expression of Ki-67 antigen in human hepatocellular carcinoma

目的:探讨原发性肝癌中Ki-67的表达和临床病理特征的关系。方法:运用免疫组化法检测肝癌切除的癌组织标本Ki-67表达水平,并分析Ki-67表达水平与多种临床病理特征之间的相关性。结果:Ki-67在48例肝癌组织中,40例有程度不同的表达,阳性率为8 3.3%,在4 8例相应癌旁组织无表达(P<0.01)。肝癌组织中Ki-67表达水平与年龄负相关(r=-0.331,P=0.011),与肝癌病理组织学分化分级正相关(r=0.361,P=0.012)。与肝硬化(r=-0.341,P=0.018)、性别(r=0.375,P=0.009)也有相关性。而与肿瘤大小、子灶、HBsAg、AFP、包膜侵犯无相关性。结论:在人肝细胞癌组织中,Ki-67的表达水平较癌旁组织高,表达强度与病理分级、年龄、性别、肝硬化有相关性。

Objective ：To study the relationship between clinical pathological features and the expression of Ki - 67 in hepatocellular carcinoma. Methods： Immunohistochemistry was used to detect the Ki - 67 expression level in cancer tissue from liver cancer resection specimens, and to analyze the correlation between Ki - 67 expression and va- rious elinicopathologieal features. Results： In 48 cases of hepatoeeHular carcinoma, Ki - 67 was expressed in 40 ca- ses, the positive rate was 83.3% , no expression 48 cases of tissue adjacent to cancer（ P 〈 0.01 ）. The expression level of Ki - 67 in HCC tissues was negatively correlated with age （ r = - 0. 331, P = 0.011 ）, positively correlated with the liver histopathologieal differentiation grade （ r = 0. 361, P = 0.012 ）, and cirrhosis （ r = - 0. 341, P = 0. 018 ）, gender （ r =0. 375, P = 0. 009 ） was also correlated with Ki - 67. But for tumor size, nodules, HBsAg, AFP and capsule invasion, no correlation was found. Conclusion ： In human hepatocellular carcinoma tissue, the expression level of Ki - 67 is higher than in noncancerous tissue, and has correlation with pathological grade, age, gender and liver cirrhosis.