MIF4GD在肝细胞肝癌组织中的表达及临床意义

The expression and clinical significance of MIF4GD in hepatocellular carcinoma tissue

目的:研究MIF4GD(middle domain of eukaryotic initiation factor 4G)在肝细胞肝癌(hepatocellular carcinoma,HCC)组织中的表达及临床意义。方法:免疫组织化学方法检测108例HCC石蜡切片中MIF4GD的表达。Kaplan-Meier生存曲线分析患者的生存率,COX模型多因素分析MIF4GD的表达与患者临床预后的相关性。结果:免疫组化结果显示MIF4GD在高分化的癌组织中表达较高,MIF4GD表达与组织分化程度、是否伴有肝硬化和有无静脉侵袭相关,差异有统计学意义(P<0.05)。生存分析表明MIF4GD高表达的患者预后良好(P<0.05)。COX模型多因素分析显示MIF4GD可以作为患者独立的预后指标(P<0.05)。结论:MIF4GD在HCC中表达下调,可能成为肝癌治疗的新靶点。

Objective：To investigate the expression and significance of Middle domain of eukaryotic initiation fac- tor 4G （MIF4GD） in hepatocellular carcinoma （HCC） tissues. Methods： Immunohistochemical analysis was used to detect the expression of MIF4GD in 108 HCC samples. Survival curve was calculated using the Kaplan - meier meth- od, and the prognosis was analyzed with multivariate COX proportional hazards regression analysis. Results：Immuno- histochemistry showed that the expression of MIF4GD was higher in well differentiated tissues. And MIF4GD expres- sion was correlated with differentiation degree, cirrhosis, and vein invasion （ P 〈 0.05 ）. The Kaplan - Meier survival curve showed that high MIF4GD expression was related to a well survival with statistical significance（ P 〈 0.05 ）. Mul- tivariate COX proportional hazards regression analysis indicated that MIF4GD expression was an independent prognos- tic marker for HCC （P 〈 0.05 ）. Conclusion：The expression of MIF4GD was downregulated significantly in HCC tis- sues, and provided a new target for therapy of HCC.