摘要
目的:探讨中药注射剂辅助PD方案治疗晚期卵巢癌的成本-效果,为临床合理用药提供参考。方法:依据不同的化疗方案将所选145例病例分为3组:A组:PD方案(n=46);B组:PD方案+康艾注射液(n=48);C组:PD方案+艾迪注射液(n=51)。每组病人进行3个治疗周期,一个周期为3周。以疗效、不良反应和生活质量作为临床观察指标,运用药物经济学成本-效果分析法评价三种化疗方案。结果:A组、B组、C组的临床治疗有效率分别为:60.87%、66.67%、68.63%。A组、B组、C组的成本分别为:23265.12、24800.35、25236.29。A组、B组、C组的C/E分别为382.21、371.99、367.72。在白细胞、肝功能异常指标上B组和C组与A组间有统计学意义差异(P<0.05),且B和C无明显差异。生活质量指标显示,3组间均相互有统计学意义差异(P<0.05)。结论:晚期卵巢癌的治疗中,中药注射剂辅助治疗是比较有效、经济的方案,同时C组即艾迪注射液辅治组最具有经济意义。
Objective: To investigate the cost - effectiveness of traditional Chinese medicine injection adjuvant PD scheme for treating advanced ovarian cancer,in order to improve clinic rational drug use. Methods: All 145 cases of advanced ovarian cancer patients were divided into three groups according to different chemotherapy scheme. Group A:PD scheme(n =46) ;Group B:PD scheme + Kangai injection(n =48) ;Group C:PD scheme + Aidi injection(n = 51 ). Every patient was treated for three periods and one period was three weeks. Clinical efficacy, adverse reaction and life quality were selected as outcome measures ; Cost - effectiveness analysis was used to evaluate the three chemo- therapy schemes. Results: The clinic effective rate : Group A ( 60.87 % ), Group B ( 66.67 % ), Group C ( 68.63 % ). The cost : Group A ( 23265.12 ), Group B ( 24800.35 ), Group C ( 25236.29 ). C/E : Group A ( 382.21 ), Group B (371.99), Group C (367.72). There were significant differences of WBC, liver function between Group B, Group C and Group A ( P 〈 0. 05 ), but there were no significant differences between Group B and Group C. There were signifi- cant differences of life quality between three groups ( P 〈 0.05 ). Conclusion: Traditional Chinese medicine injection adjuvant therapy on advanced ovarian cancer was effective and economic scheme and Aidi injection ( Group C) was most economic significance.
出处
《现代肿瘤医学》
CAS
2013年第12期2796-2798,共3页
Journal of Modern Oncology
关键词
晚期卵巢癌
中药注射剂
辅助治疗
化疗
药物经济学
advanced ovarian cancer
traditional Chinese medicine injection
adjuvant therapy
chemotherapy
phar-macoeconomics