期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

VEGF-C/VEGFR-3在恶性肿瘤淋巴转移中的作用及研究进展 被引量：8

Research progress of the effect of VEGFC/VEGFR-3 in malignant tumor lymph node metastases
下载PDF
导出
摘要 肿瘤分泌的VEGF-C与VEGFR-3结合后可诱导淋巴管内皮细胞增殖和迁移,刺激淋巴管的新生,介导肿瘤淋巴管的转移。通过竞争性抑制VEGFR-3的信号转导可有效阻止肿瘤淋巴管的转移,最终达到提高肿瘤治疗效果的作用。 Tumor secretion of combined VEGF -C and VEGFR -3 can be induced lymphatic endothelial cell prolif- eration and migration, stimulating lymphangial freshman, mediated tumor lymphatic transfer. Through the competitive inhibition VEGFR -3 signal transduction can effectively prevent tumor lymphatic transfer, and ultimately improve the effect of treatment of cancer.
作者 李晖 李亭葶 王熙才
机构地区 昆明医科大学第三附属医院肿瘤研究所
出处 《现代肿瘤医学》 CAS 2013年第12期2875-2877,共3页 Journal of Modern Oncology
基金 国家自然科学基金资助项目(编号:81060177) 云南省卫生厅专项基金资助项目(编号:2012WS0041)
关键词 VEGF—C VEGFR-3 恶性肿瘤 淋巴转移 VEGF - C/VEGFR - 3 malignant tumor lymph node metastases
分类号 R73-37 [医药卫生—肿瘤]
  • 相关文献

参考文献19

  • 1Joukov V, Pajusola K, Kalpainen A, et al. A novel vascular endothe- lial growth factor, VEGF - C, is a ligand for the Flt 4 ( VEGFR - 3 ) and KDR( VEGFR - 2 ) receptor tyrosine kinases [ J ]. EMBO J, 1996,15(2) :290 -298.
  • 2Oliver G. Lymphatic vasculature development [ J ]. Nat Rev Immu- no1,2004,4 ( i ) :35 - 45.
  • 3Katsuta Miwako, Miyashita Masao, Makino Hiroshi, et al. Correla- tion of hypoxia inducible factor - 1 alpha with lymphatic metastasis via vascular endothelial growth factor - C in human esophageal cancer[J]. Exp Molr Pathol,2005,78(2) :123 - 130.
  • 4Cross M J, Dixelius J, Matsumoto T, et al. VEGF - receptor signal transduction [ J ]. Trends Biochem Sci,2003,28 (9) :488 - 494.
  • 5Achen MG, Mann GB, Stacker SA. Targeting lymphangiogenesis to prevent tumour metastasis[ J ]. Br J Cancer, 2006,94 (10) : 1355 - 1360.
  • 6商嵩山,张剑权.VEGF-C、VEGFR-3在肿瘤淋巴管生成中作用的研究进展[J].现代肿瘤医学,2011,19(1):185-188. 被引量：15
  • 7Karkkainen M J, Haiko P, Sainio K, et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic ves- sels from embryonic veins [ J ]. Nat Immunol,2004,5:74 - 80.
  • 8Kimura H, Kato H, Tanaka N, et al. Preoperative serum vascular en- dothelial growth factor - C ( VEGF - C ) levels predict recurrence in patients with esophageal cancer [ J ]. Anticancer Res, 2008,28 (1A) :165 -169.
  • 9Hachisuka T, Narikivo M, Yamada Y, et al. High lymphatatic vessel density correlates with overexpression of VEGF - C in gastric canc-er [ J ]. Oncol Rep,2005,13 (4) :733 - 777.
  • 10石小燕,胡国清,曹荣华.VEGF-C及其受体VEGFR-3/Flt-4与肿瘤淋巴管生成、增殖及转移关系的研究[J].中华放射肿瘤学杂志,2003,4:51.

二级参考文献49

  • 1张孝艳,乔玉环,史惠蓉.VEGF-C与妇科肿瘤关系的研究进展[J].国外医学（妇产科学分册）,2005,32(3):180-183. 被引量：1
  • 2马凤江,智绪亭.血管内皮生长因子-C在胃癌组织中的表达及与肿瘤淋巴结转移的关系[J].肿瘤防治杂志,2005,12(4):281-282. 被引量：12
  • 3Salven P, Lymlxussak A, Heikkila P, et al. Vaseular endothelial Growth facter VEGF-B and VEGF-C are expressed in human tumor [ J ]. J Pathol, 1998,153 ( 1 ) : 103-108.
  • 4Lagercrantz J, Farnebo F, Larsson C, et al. A comparative study of the expression patterns for vegf, vegf-b/vrf and vegf-c in the developing and adult mouse [ J ]. BIOchem Biophys Acta, 1998,1398 (2) : 157- 163.
  • 5Enholm B, Pavonen A, Ristimaki A, et al. Comparison of VEGF, VEGF-B, VEGF-C and ang-1 mRNA regulation by serum, growth factors, oncoproteins and hypoxia [ J ]. Oncogene, 1997,14 ( 20 ) : 2475-2483.
  • 6Salven P, Lymboussaki A, Heikkila P, et al. Vascular endothelial growth factors VEGF-B and VEGF-C are expressed in human tumors [ J]. Am J Pathol, 1998,153 ( 1 ) : 103-108.
  • 7Olofeson B, Korpelainen E, Pepper MS, et al. Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells [ J]. Proc Natl Acad Sci USA, 1998,95 (20) : 11709-11714.
  • 8Ristimaki A, Narko K, Enholm B, et al. Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C[ J]. J Biol Chem,1998,273(14) :8413-8418.
  • 9Banga JD. Therapeutic angiogenes Is through injection Of gene for vascular endothelial growth factor (VEGF) [ J ]. Ned Tijdschr Geneeskd, 2000,144 ( 3 ) : 113-116.
  • 10Karkkainen MJ,Petrova T. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis[ J]. Oncogene, 2000,19 ( 49 ) : 5598 -5605.

共引文献25

同被引文献87

  • 1陈敏,唐建武.VEGF-C在非小细胞肺癌中的表达及意义[J].肿瘤,2005,25(1):80-82. 被引量：8
  • 2刘冬菊,娄阁.VEGF-C及受体VEGFR-3在宫颈癌中的表达及临床意义[J].实用妇产科杂志,2005,21(8):475-477. 被引量：4
  • 3李炜,孟艳冬,赵玲,丁诗语,孙莉.灯盏细辛注射液对MCF-7细胞凋亡及血管生成作用的实验研究[J].甘肃中医,2006,19(9):47-49. 被引量：4
  • 4范跃祖,李光明,黄国平,李新平.检测微淋巴管及其密度和血管内皮生长因子C对结直肠癌的临床意义[J].中华胃肠外科杂志,2006,9(6):477-482. 被引量：7
  • 5Ryeom S, Folkman J. Role of endogenous angiogenesis inhibitors in down syndrome[ J]. J Craniofac Surg,2009,20 ( 5 ) : 1629 - 1630.
  • 6Roskoskir R Jr. Vascular endothelial growth factor(VEGF) signa- ling in tumor progression [ J ]. Crit Rev Oncol Hematol, 2007,62 (3) :179 -213.
  • 7Carrillo de Santa Pau E, Arias FC, Caso Pelaez E, et al. Prognostic significance of the expression of vascular endothelial growth factors A, B, C, and D and their receptors R1, R2, and R3 in patients with non - small cell lung cancer [ J ]. Cancer, 2009,115 ( 8 ) : 1701 - 1712.
  • 8Joukov V, Sorsa T, Kumar V, et al. Proteolytic processing regulates receptor specificity and activity of VEGF - C [ J ]. EMBO J, 1997, 16(13) :3898 -3911.
  • 9Huang HY, Ho CC, Huang PH, et al. Co - expression of VEGF - C and its receptor, VEGFR- 2 and VEGFR- 3, in endothelial ceils of lymphangioma. Implication inautocrine or paracrine regulation of lymphangioma [ J]. Lab Invest ,2001,81 ( 12 ) : 1729 - 1734.
  • 10Kajita T, Ohta Y, Kimura K, et al. The expression of vascular endo- thelial growth factor C and its receptors in non - small cell lung cancer[ J]. Br J Cancer,2001,85 (2) :255 - 260.

引证文献8

二级引证文献46

现代肿瘤医学
2013年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部