严重颅脑创伤后误吸成分对血浆及肺泡液中IL-8水平的影响

Effects of different aspiration components on IL-8in plasma and alveolar fluid in patients with severe craniocerebral trauma

目的探讨严重颅脑创伤后不同误吸成分对血液及肺泡液中IL-8水平的影响。方法30例重度颅脑创伤患者均分为三组:A组无误吸,B组误吸胃液,C组误吸血液。于气管插管完毕后1、12、24、48h采血样和收集肺泡液,采用ELISA法测定IL-8水平。结果创伤后24h,B、C组血浆IL-8水平高于A组(P<0.05),C组高于B组(P<0.05)。B、C组12、24、48h肺泡液IL-8水平较1h时升高(P<0.05),B、C组各时间点肺泡液IL-8水平均高于A组(P<0.05),C组高于B组(P<0.05)。结论颅脑创伤后误吸患者血浆和肺泡液中IL-8释放和激活可能与其引发肺损伤及全身凝血功能障碍有关。

Objective To explore the effects of different aspiration components on interleukin-8 （IL-8） in plasma and alveolar fluid after severe craniocerebral trauma. Methods Thirty patients with severe craniocerebral trauma were divided into three groups of A（no aspiration）, B（gastric aspiration） and C（blood aspiration）. Blood and alveolar fluid samples were collected at the 1st, 12th, 24th and 48th hour after tracheal intubation for detecting IL-8 expression by ELISA. Results At the 24th hour after trauma,plasma IL-8 expression was higher in groups of B and C than that in group A（P〈0. 05）, which was higher in group C than that in group B（P〈0. 05）. IL-8 expression in alveolar fluid was higher at the 12th ,24th and 48th hour after trauma than that at the first hour after trauma in groups of B and C（P〈0. 05）. IL-8 expressions in alveolar fluid in all time points after trauma were higher in groups of B and C than those in group A（P〈0. 05）. Conclusion Release and activation of IL-8 in plasma and alveolar fluid may be related to aspiration-related lung injury and coagulation disorders after craniocerebral trauma.