摘要
目的:比较保乳术与改良根治术对育龄期乳腺癌患者术后复发及生存情况。方法:收集2005年1月—2010年6月收治的育龄期乳腺癌82例临床资料,其中行保乳手术48例(保乳组),乳腺癌改良根治术34例(改良根治组)。对两组患者手术情况、并发症、复发、转移及生活质量进行评估。结果:与改良根治组比较,保乳组手术时间[(74.4±8.3)min vs.(92.6±10.7)min]、术中出血量[(46.8±6.7)mL vs.(77.0±68.4)mL]、引流量[(398.8±41.3)mL vs.(601.4±62.7)mL]均明显减少、住院时间明显缩短[(13.4±3.2)d vs.(17.9±2.8)d],并发症发生率明显降低(6.3%vs.14.7%)(均P<0.05);两组1,2年复发和转移率比较,差异无统计学意义(P>0.05);保乳组的社会功能、情绪功能、角色功能和躯体功能评分均高于改良根治组(均P<0.05)。结论:对育龄期乳腺癌患者,保乳术与改良根治术在复发和转移方面无差异,但前者术后的生存质量优于后者。
Objective: To compare the postoperative recurrence and survival between breast-conserving surgery and modified radical operation in breast cancer women in child bearing age. Methods: ~he clinical data of 82 breast cancer women in child bearing age admitted from January 2005 to June 2010 were collected. Of the patients, 48 cases (breast-conserving group) underwent breast-conserving therapy and 34 cases (modified radical operation group) were subjected to modified radical operation. ~he intraoperative conditions, postoperative complications, recurrence, metastasis, and quality of life of the two groups of patients were analyzed. Results: In breast-conserving group compared with modified radical operation group, the operative time [(74.4+8.3) min vs. (92.6+_10.7) mini, intraoperative blood loss [(46.8+6.7) mL vs. (77.0+-68.4) mL] and drainage volume [(398.8+-41.3) mL vs. (601.4+62.7) mL] were significantly reduced, the length of hospital stay [ (13.4+3.2) d vs. (17.9+-2.8) d] was significantly shortened, and the incidence of postoperative complications (6.3% vs. 14.7%) was significantly decreased (all P〈0.05). The 1- and 2-year recurrence or metastasis rate showed no statistical difference between the two groups (P〉0.05). The scores for social, emotional, role and physical function in breast-conserving group were all significantly higher than those in modified radical operation group (all P〈0.05). Conclusion: For breast cancer women in child bearing age, breast-conserving surgery is similar to modified radical operation in regard to postoperative recurrence and metastasis, but the former is superior to the latter in respect to postoperative quality of life.
出处
《中国普通外科杂志》
CAS
CSCD
北大核心
2013年第11期1398-1402,共5页
China Journal of General Surgery
关键词
乳腺肿瘤
外科学
保乳术
改良根治术
生存质量
Breast Neoplasms/surg
Breast Conserving Surgery
Modified Radical Operation
Life Quality