鲑鱼降钙素和依降钙素缓解骨质疏松疼痛的临床对比研究

目的对鲑鱼降钙素和依降钙素缓解重度骨质疏松疼痛的临床疗效进行对比。方法选择2009年6月-2013年2月,符合骨质疏松诊断标准、疼痛评分在7分以上患者20例,随机分为鲑鱼降钙素组10例、依降钙素组10例,分别给予肌注射鲑鱼降钙素,1次/d,每次50 U,和肌注射依降钙素,1次/d,每次20 U,均连续2周。观察治疗2周后患者的临床疗效并观察疼痛的变化,3个月后随访观察患者的疼痛评分变化。结果鲑鱼降钙素组显效效8例,有效2例;依降钙素组显效4例,有效4例,无效2例,鲑鱼降钙素组优于依降钙素组。疼痛评分:鲑鱼降钙素组治疗前评分(8.12±2.32),治疗后评分(2.33±1.22),依降钙素组治疗前评分(8.09±2.72),治疗后评分(4.21±1.51)。两组治疗前后自身比较差异有统计学意义(P<0.05),治疗后组间疼痛评分比较,差异有统计学意义(P<0.05)。结论本研究表明在鲑鱼降钙素在缓解原发性骨质疏松疼痛的临床疗效上优于依降钙素。

Objective Gaining and lcitonin severe osteoporosis pain. Methods In the hospital from 2009 to 2013, in accordance with the diagnostic criteria of osteoporosis, pain score more than 7 points, randomly divided into group 10 cases, group 10 cases, the therapeutic effect after 2 weeks and the changes of pain. Results Salmon calcitonin group effect in 8 cases, effective in 2 cases;elcatonin group 4 cases, effective 4 cases, invalid 2 cases, salmon calcitonin group is better than the elcatonin group. Pain scores：salmon calcitonin group before treatment score was （8.12 ± 2.32）, after treatment score was （2.33 ± 1.22）, elcatonin group before treatment was （8.09 ± 2.72）, after treatment score was （4.21 ± 1.51）. There are statistically significant differences between the two groups before and after the treatment itself （P〈0.05）, compare the pain scores after treatment, the difference was statistically significant （P〈0.05）. Conclusion Clinical curative effect of miacalcic in remission of primary osteoporosis pain is better than the elcitonin.