谷维素和红豆杉胶囊联合放疗治疗中晚期宫颈癌临床观察

目的探讨谷维素和红豆杉胶囊联合根治性放疗治疗宫颈癌的疗效及不良反应。方法选择萍乡市妇幼保健院2010年1月-2013年4月50例宫颈癌中晚期患者,随机分成观察组24例和对照组26例。观察组采用谷维素+红豆杉胶囊联合根治性放疗,对照组采取紫杉醇+卡铂(TC)方案联合根治性放疗,对比两组疗效及不良反应。结果观察组和对照组的总有效率(CP+PR)分别为66.6%和69.2%。两组总有效率比较,差异无统计学意义(P<0.05)。观察组轻度不良反应发生率为83.3%,重度为16.7%;对照组为轻度30.7%,重度为79.3%,两组比较差异有统计学意义(P>0.05)。两组治疗效果差异无统计学意义(P<0.05),观察组严重不良反应少。结论谷维素和红豆杉胶囊辅助放疗能起到缩小肿瘤、延长生存率作用,而且能减少化疗不良反应。

Objective To study curative effect and adverse reaction of the oryzanol＋yew capsule combined radical therapy to treat cervical cancer.Methods Selected 50 cases of cervical cancer in Pingxiang Maternity＆Child Care Hosptial from January 2010 to April 2013 and divided them into two groups. Observation group were given oryzanol＋yew capsule combined radical radiotherapy, contrast group were given paclitaxel plus carboplatin combined radical radiotherapy （TC）.Then compared the curative effect and adverse reactions in two groups. Results Observation group and control group total effective rate （CP＋PR） was 66.6%and 66.6%respectively. Compare two groups total effective rate, there was no statistically significant difference （P〉0.05）. Observation group the incidence of mild adverse reaction was 83.3%, heavy is 16.7%;Control group for mild 30.7%,severe （79.3%）, comparing the two groups was statistically significant difference （P〈0.05）.There were no ignificant difference（P〉0.05） in treatment effect in two groups and neither of them have more serious adverse reaction. Conclusion Radical therapy in auxiliary through oryzanol combine yew capsule can shrink the tumor, prolong the survival rate and reduce side effects on chemotherapy.