人乳头瘤状病毒亚型在河南新乡的分布特征

目的：报告人乳头瘤状病毒亚型在河南新乡地区的分布特征。方法分析2009年8月-2011年9月在新乡中心医院就诊的2294例女性的宫颈分泌物标本，用MY 09/11 PCR技术及反向点杂交检测病毒基因型。结果人乳头瘤病毒总感染率31.0％，其中多重感染率8.9％，最常见的亚型为HPVl 6（10.3%），其次是HPV 11,6,58。各年龄组患病率不同，中年女性所占比例最高。除30～39岁和40～49岁组间P〉0.05外，其余年龄组间感染率均有显著性差异（P〈0.05）。HPV 16亚型在各年龄组均是主要高危感染型，58亚型位居第二。结论该地区相对高的感染率以及流行亚型分布特征，提示研发针对HPV 16，58,52和33亚型疫苗的必要性。

Objective The Objective of this study was to report the subtype distribution of the human papillomavirus in Xinxian China. Methods Type-specific prevalence and extent of multiple infections were assessed in cervical cell samples collected from the 2294 patients from Aug. 2009 to Sept. 2011 at Xinxiang Central Hospital in Xinxiang P. R. China, a statistically representative of married and small part of unmarried woman at this area, using MY 09/11 PCR and reverse dot blot hybridization for genotyping of 21 kinds of HPV subtypes. The Chi-square test was used to compare HPV prevalence across age groups. Results Human papillomavirus prevalence was 31.0%overall and multiple type infection was 8.9%. The most common identified HPV type was HPV 16 （10.3%）, followed by HPV 11, 6, 58. HPV prevalence was different across age groups. The lowest prevalence estimate was seen in the over 50 year age group, while the highest among middle aged women. There are statistical significance （P〈0.05） among age groups except between group 30-39 years and 40-49 years. HPV 16 were main identified high-risk types for woman in each age group. HPV 58 followed except group 30-39 years （HPV 33 took the second ）.Conclusion A relatively high prevalence and different pattern of epidemiology of HPV infection in Xinxiang China shows the necessity of developing specific vaccines directly to HPV subtype 16,58, 52 and 33.