α干扰素治疗小儿慢性肝炎副作用的长期观察

Side effects after treatment with α interferon in children with chronic viral hepatitis

目的 了解应用基因工程α干扰素治疗小儿慢性病毒性肝炎的近、远期副作用发生情况。方法 2 6 1例慢性肝炎随机分组 ,用α干扰素治疗 ,以 114例同期治疗的成人病毒性肝炎做对照 ,观察副作用。观察时间平均 5～ 6年 ,最长 10年。结果 近期副作用主要表现为中、低度发热。小儿发热≤ 38℃组比成人少 (χ2 =2 2 .3 ,P <0 .0 0 1) ,流感样症状也少于成人 (χ2 =16 .1,P <0 .0 0 1)。长期观察部分类风湿因子阳性、抗核抗体阳性者 (2 % )未影响治疗。治疗对甲状腺功能 (血清T3 ,T4,TSH)和肾功能 (BUN ,Cr)也无影响。不同的肝病病因 (乙型和丙型 )、病理改变 (≤G2组和≥G3组 )患儿发生副作用无差别。

Objective This paper aimed at a long term observation on side effects of α IFN treatment in children with chronic viral hepatitis. Methods A randomized trial of 261 α IFN treated chronic hepatitis children (183 with hepatitis B,78 with hepatitis C) in comparison with 114 adults was carried out to observe side effect of α IFN treatment 5 6 years in average and 10 years the longest. Mean age of children was 8.7 years, with 203 males and 58 females. Results Early stage side effects were low to moderate fever and endemic influenza symptoms, which in children were more less than in adults ( P < 0.001 ). Side effects did not relate to viral pathogeny (HB or HC) and pathological changes (≤G2,≥G3) in child patient. Slightly poor appetite,slight hair loss, rash and tinnitus would disappear gradually needed no treatment.Serum Bil,Bun,Cr,T3,T4 and TSH were normal in all patients. There was no long term side effects.Conclusion α IFN treatment for viral hepatitis in children is safe.