HSP60在胃癌中的表达

Expression of Heat Shock Protein 60 in Human Gastric Cancer

为研究热休克蛋白 6 0 (HSP6 0 )在人胃癌组织中的表达 ,对 6 0例非癌胃粘膜病变和 5 0例胃癌组织手术、胃镜活检石蜡标本 ,应用免疫组织化学方法检测 HSP的表达。结果显示 :HSP6 0在肠上皮化生、不典型增生及胃癌中的阳性率和过表达率均明显高于慢性浅表性胃炎 (P <0 .0 5 ) ;在胃癌组织中的过表达率高于肠上皮化生和不典型增生 (P <0 .0 5 )。HSP6 0在不同分化程度胃癌中表达无明显差异 (P >0 .0 5 ) ;在胃癌组织的过表达率高于肠上皮化生和不典型增生 (P <0 .0 5 )。 HSP6 0在不同分化程度胃癌中表达无明显差异 (P >0 .0 5 )。结果表明 ,HSP6 0在人胃癌、癌前情况和病变中过度表达可能与胃癌的发生、发展有关。

In order to research the expression of heat shock protein 60(HSP60) in human gastric cancer tissue ,immunohistochemistry staining was used in clinical specimens of 50 cases of human gastric cancer and 60 cases of noncancer chronic gastric mucosal lesion with monoclonal antibody against human HSP60 .The results showed that the positive staining rate in intestinal metaplasia,dysplasia and gastric cancer is higher than that in chronic superficial gastritis(P>0.05) .HSP60 was obviously overexpressed in gastric cancer as compared to that in intestinal and dysplasia (P<0.05).The exprissions of HSP60 in different differentiation of gastric cancers were not different (P>0.05).The results indicated that HSP60 is expressed in human gastric cancer,which might contribute to the origin and developmtent of the cancer.