脑缺血损伤机制和治疗策略研究进展

Progress in mechanisms of cerebral ischemia and therapeutic strategies

缺血性中风是目前严重威胁人类健康的几种疾病之一 ,对其损伤机制的研究正逐步深入 ,除兴奋性毒性、钙超载外 ,还包括细胞凋亡、炎症、自由基、一氧化氮以及线粒体的损伤 ,同时 ,机体亦有内在的保护机制。尽管临床治疗仍以溶栓为主 ,谷氨酸受体拮抗剂、钙拮抗剂。

Ischemic stroke is one of the diseases that severely threaten human health,the mechanisms underlying its injury have been gradually elucidated.Besides the excitotoxicity and calcium overload,the causes also include apoptosis,inflammation,free radicals,NO and dysfunction of mitochondria,in the mean time,the body also has internal protective mechanism.Although antithrombotic agents are still main clinical drugs,there are some progresses in neuroprotective effects of glutamate receptor antagonist,calcium channel antagonists,free radical scavengers and caspase inhibitors in the treatment of ischemic stroke.[