细胞凋亡与治疗心力衰竭的药物

Apoptosis and drugs of treating heart failure

细胞凋亡日益渗入心力衰竭研究领域。本文阐述了心力衰竭中凋亡的基因调控、触发因素、信号转导途径等机制 ,以及卡维地洛、维司力农、血管紧张素转换酶抑制剂、血管紧张素II受体阻滞剂等治疗心力衰竭药物最新发现的药理作用机制———抑制凋亡。

Apoptosis increasingly infiltrated into the field of cardiovascular research.In this paper,mechanisms of apoptosis gene in mediating heart failure,its trigger factor and signal pathway as well as the newly discovered pharmacological mechanism—inhibition of apoptosis—of pharmaceuticals for treatment of heart failure such as carvedilol,vesnarinone,ACE inhibitors and angiotensin Ⅱ receptor antagonists were introduced.Investigation and development of drugs for treatment of heart failure in terms of apoptosis may be the novel approches for prevention and treatment of heart failure. [