蒙诺和钠催离对充血性心力衰竭患者血清地高辛浓度及心功能的影响和比较

The effect of fosinopril and indapamide on serum digoxin concentration and heart function of patients with chronic congestive heart failure

目的 :观察蒙诺和钠催离在治疗充血性心力衰竭患者时对血清地高辛浓度 (SDC)及心功能的影响并对二者进行比较。方法 :30例患者随机分为二组 ,基础治疗为地高辛 0 .2 5mg ,qd ,7d后分别加用蒙诺 10mg或钠催离 2 .5mg ,分别于加用后 7,14d抽血查血清地高辛浓度、肾肌酐清除率、地高辛清除率并评估心功能。 结果 :2周后 ,蒙诺组及钠催离组在自身比较中对SDC均无明显影响 ,但二组比较显示蒙诺对SDC的影响较钠催离为大 ,(P <0 .0 5 )。对心功能的改善二组相同 ,未见到明显的不良反应。结论

Objectives:As stated in the title.Methods:30 patients with chronic congestive heart failure(CHF) were treated with once daily 0.25 mg digoxin for 7 days,then they were equally divided to receive once daily 10 mg fosinopril or 2.5 mg indapamide in addition to 0.25 mg digoxin.Their serum digoxin concentration,creatinine clearance,and heart function were evaluated after 7d,14d, and 21d treatment.Results:Fosinopril or indapamide showed no significant effect on serum digoxin concentration after 2 weeks treatment but the effect of indapamide was even bigger than fosinopril.The heart function was improved in both groups.Conclusions:The heart function of CHF patients were significantly improved when low dose of digoxin and fosinopril or indapamide combined therapy was adopted. [