洛索洛芬治疗膝骨关节炎的临床评价

The clinical evaluation of loxoprofen sodium in the treatment of patients with knee osteoarthritis

目的 :观察洛索洛芬 (乐松 )治疗膝骨关节炎 (OA)的疗效和安全性。方法 :选择 114例膝OA患者 ,口服乐松 ,6 0mg ,tid。分别在 0周和第 3周末进行疗效和安全性评估 ,疗效指标包括休息时痛、活动痛指数、关节压痛、关节肿胀和关节活动度等 5项指标。结果 :完成疗程、资料齐全的患者共 10 6例。经过 3周的治疗 ,乐松对患者5项疗效指标均有明显改善 (P <0 .0 1) ,各项指标的有效率均超过 80 .0 % ;医师和患者对疗效评定的总有效率分别为 89.6 2 %和 91.5 1%。 13例 (12 .2 6 % )患者出现了与药物相关的不良反应 ,全部为胃肠道症状 ,勿需减量或停药 1周内症状消失。无严重的或危及生命的不良反应发生。结论 :乐松具有强大的消炎镇痛作用 ,不良反应轻 。

Objective:To study the efficacy and safety of loxoprofen sodium in the treatment of patients with knee osteoarthritis(OA).Methods:114 patients with OA in knees were enrolled in a random order,open trial. Each patient received loxoprofen sodium at a dosage of 60mg, tid, taking after the food.The efficacy and safety of loxoprofen sodium was evaluated prior to and after 3 weeks of medication.The efficacy indices include rest pain index, active pain index, tenderness index, swelling index and activity degree of the knee joint.Results:All data were available in 106 patients who completed the trial. All five clinical indices improved with statistical significance( P <0.01)after 3 weeks'treatment.Each index had an efficacy rate of over 80.0%.The total efficacy rate evaluated by the investigators and patients were 89.62% and 91.51% respectively.13 patients ( 12.26% ) developed side effects,all of which were GI symptoms and were observed during the first week and disappeared within one week without any treatment.No liver or kidney dysfunction was found and no serious or vital side effect appeared.Conclusion:Loxoprofen sodium possesses a strong analgesic and anti inflammatory property with low side effects and good tolerance. [