摘要
血清中胆固醇水平高是冠心病等疾病的重要原因。在当前吸附法治疗高脂血症的推广应用中，所用吸附剂不是价格过于昂贵就是性能不稳定，很难应用于临床。本文试图以具有优良血液相容性和吸附性的壳聚糖用作胆固醇吸附剂。 通过 Ｈａｃｋｍａｎ法制备了壳聚精，并研磨成 ７５～１５０μｍ的粉末，加入血清中吸附，用酶氧化法测量吸附量。 实验中发现壳聚糖对胆固醇的吸附与壳聚糖脱乙酸化程度、分子量有密切关系，实验结果表明：随壳聚糖脱乙酸化度提高，壳聚糖对胆固醇吸附量也提高，当壳聚糖分子量为５３～５４万时，吸附量达到最大值，吸附量还跟壳聚糖形态有关，壳聚精粉末粒径越小越利于吸附。
Chitosan, which was prepared by the method of Hackman and used in size of powder with diameter 75-150 μm, was applied to absorb cholesterol in serum in vitro,and the adsorption capacity was measured by means of enzyme oxidation method. The results show that the absorption capacity increases with the increasing of deaceylation degree of chitosan and the total powder surface,and a range of molecular weight of 5. 3-5.4 x 10~5 was found to be the most suitable molecular weight for chitosan absorbing cholesterol.
出处
《天然产物研究与开发》
CAS
CSCD
1999年第6期54-57,共4页
Natural Product Research and Development
