内蒙古地产紫沙参多糖免疫功能

STUDY ON THE PHARMACODYNAMICS OF POLYSACCHARIDE OF AOENOPHORA PANICULATE GROWING THE INNER MONGOLIA ON IMMUNE FUNCTION

给小鼠灌胃口服紫沙参多糖 ４００ ｍｇ· ｋｇ－１、８００ ｍｇ· ｋｇ－１，观察其连续给药对免疫功能的影响。结果显示：在５ｄ后能显著地增加小鼠耳肿胀度，提示紫沙参多糖能够增强二硝基氯苯诱导的小鼠迟发性变态反应（ＤＴＨ）；在７ ｄ后能显著地增加碳粒廓清指数Ｋ和吞噬指数α，增强单核巨噬细胞的吞噬功能，能显著地增加免疫器官胸腺、脾脏重量，增强机体免疫作用。试验采用国家中药二类新药云芝多糖 １０００ ｍｇ· ｋｇ－１作为阳性对照组。

To determine the effects of polysaccharide of A. panicatate on immune function, 400 mg. kg-1, 800 mg. kg-1 polysaccharide were fed to mice. The results showed that markedly increased swelling degree of mice ear ofter 5 days, which represented the mice DTH induced by dinitrofluo- robenzene could raised with polysaccharide of A. Panicatat; In addition, markedly increased the clearance rate K of charcoal particles and the phagocytic index a ofter 7 days, raised the phagocytosis of monocyte macrophage, the weight of immune organes thymus and spleen, rised the immune modulatory action. The polystictus polysaccharide 1000 mg. kg-1 was control sample.