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Reprimo基因甲基化与肿瘤关系的研究进展 被引量：3

Research progress in relationship of Reprimo methylation with tumors
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摘要 Reprimo基因甲基化参与了多种类型肿瘤的发生和发展,近年来越来越受到医学界的重视,Reprimo基因甲基化是最值得期待的肿瘤生物标志物之一。通过回顾近年对Reprimo基因的研究进展情况,认为Reprimo基因甲基化有望用于肿瘤发病机制、早期诊断、指导药物靶向治疗及预后评估等研究中,对人类健康具有重要意义。 Reprimo methylation plays an important role in the development of tumors. In the last decades, Reprimo methylation gets more and more attention of medical community. Reprimo methylation is one of the most worth looking forward to the biomarkers of tumors. Through the review of recent research progress of Reprimo, Reprimo methylation is expected to be used in tumor pathogenesis, early diagnosis and guiding drug targeted therapy study, there is a great significance on human health.
作者 张瑜 白玉贤
机构地区 哈尔滨市医科大学附属肿瘤医院内二科
出处 《中国医药导报》 CAS 2013年第35期39-42,共4页 China Medical Herald
关键词 Reprimo 基因甲基化 肿瘤 诊断 治疗 Reprimo Methylation Tumor Diagnosis Treatment
分类号 R733 [医药卫生—肿瘤]
  • 相关文献

参考文献18

  • 1Esteller M. Cancer epigenomics:DNA methylomes and histone- modification maps [J]. Nat Rev Genet,2007,8 (4):286-298.
  • 2Ohki R,Nemoto J, Murasawa H, et al. Reprimo,a new candi- date mediator of the p53-mediated cell cycle arrest at the G2 phase [J]. Biol Chem, 2000,275 (30) : 22627-22630.
  • 3Takahashi T, Suzuki M, Shigematsu H, et al. Aberrant methyla- tion of reprimo in human malignancies [J]. Int J Cancer, 2005, 115(4) :503-510.
  • 4Bernal C, Aguayo F, Villarroel C, et al. Reprimo as a potential biomarker for early detection in gastric cancer [J]. Clin Can- cer Res, 2008,14 (19) : 6264-6269.
  • 5Suzuki M,Shigematsu H,Takahashi T,et al. Aberrant methy- lation of reprimo in lung cancer [J]. Lung Cancer,2005,47(3 ) : 309-314.
  • 6姜蕊,于世英.非小细胞肺癌中Reprimo以及14-3-3 Σ基因启动子异常甲基化检测[J].肿瘤防治研究,2009,36(2):106-109. 被引量：4
  • 7Wong TS,Kwong DL,Sham JS,et al. Methylation status of reprimo in head and neck carcinomas [J]. Int J Cancer,2005,117(4): 697.
  • 8Hamilton JP, Sato F, Jin Z, et al. Reprimo methylation is a potential biomarker of Barrett's-Associated esophageal neoplastic progression [J]. Clin Cancer Res, 2006,12 (22) : 6637-6642.
  • 9Sato N,Fukushima N, Matsubayashi H,et al. Aberrant methy- lation of reprimo correlates with genetic instability and pre- dicts poor prognosis in pancreatic ductal adenocarcinoma [J] Cancer, 2006,107 (2) : 251-257.
  • 10王海,胡世莲,沈干,等.5-AzadC联合TSA对人胃癌SGC-7901细胞生长及Reprimo基因表达的影响[J].安徽科技大学学报,2012,47(1):1-4.

二级参考文献24

  • 1杨维良,张新晨.胃癌基因治疗的现状及展望[J].中华实验外科杂志,2004,21(5):639-640. 被引量：11
  • 2汪必成,刘志苏.钙结合蛋白S100A2在肝癌中的表达及与肿瘤细胞增殖的关系[J].中华实验外科杂志,2007,24(7):790-791. 被引量：5
  • 3Wicki R, Franze C, Scholl FA, et al. Repression of the candidate tumor suppressor gene S100A2 in breast cancer is mediated by site specific hypermethylation. Cell Calcium, 1997,22 : 243-254.
  • 4Ohki R, Nemoto J, Murasawa H, et al. Reprimo, a new candidate mediator of the p53-mediated cell cycle arrest at the G2 phase. J Biol Chem ,2000,275:22627-22630.
  • 5Taylor WR,Stark GR. Regulation of the G2/M transition by p53. Oncogene,2001,20 : 1803-1815.
  • 6Takahashi T,Suzuki M,Shigematsu H,et al.Aberrant methylation of reprimo in human malignancies[J].Int J Cancer,2005,115(4):503-510.
  • 7Osada H,Tatematsu Y,Yatabe Y,et al.Frequent and histological typespecific inactivation of 14-3-3s in human lung cancer[J].Oncogene,2002,21(15):2418-2424.
  • 8Suzuki M,Shigematsu H,Takahashi T,et al.Aberrant methylation of Reprimo in lung cancer[J].Lung Cancer,2005,47(3):309-314.
  • 9Chan TA,Hermeking H,Lengauer C,et al.14-3-3 Sigma is required to prevent mitotic catastrophe after DNA damage[J].Nature,1999,401(6753):616-620.
  • 10Waki T,Tamura G,Sato M,et al.Agerelated methylation of tumor suppressor and tumorrelated genes: an analysis of autopsy samples[J].Oncogene,2003,22(26):4128-4133.

共引文献6

同被引文献35

  • 1黄开红,刘建化,李学先,宋立兵,曾木圣,郭宝红.Bmi-1在胃癌组织中的表达及相关性研究[J].中国肿瘤临床,2007,34(17):961-965. 被引量：16
  • 2王海,胡世莲,沈干,等.5-AzadC联合TSA对人胃癌SGC-7901细胞生长及Reprimo基因表达的影响[J].安徽科技大学学报,2012,47(1):1-4.
  • 3Esteller T. Deteetion and interpretation of altered meth- ylation patems in cancer cells[J]. N EngL J Med, 2008, 358(11) ;48-51.
  • 4Takahashi T, Suzuki M, Shigematsu H, et al. Aberrant methylation of Reprimo in human malignancies [J]. Int J Cancer ,2005,115(4) ;503-510.
  • 5Dirnu R, Secureanu FA, Neamtu C,et al. Chronic gastri- tis with intestinal metaplasia: Clinico-statistical, histolog- ical and immunohistochemical study[J]. Rom J Morphol Embryol. 2012;53(2) :293-7.
  • 6Bird A . Perceptions of pigenetics[J]. Nature, 2007,447 (7143) : 396 -398.
  • 7Yamamoto E,Suzuki H, Tanlar UH,et al. Role of DNA methylation in the development of diffuse-type gastrie cancer[J]. Digestion, 2011,83 (4) : 241-249.
  • 8Gazdar AF, Takahashi T, Suzuki M, et al. Aberrant methylation of Reprimo in human malignancies[J]. Int J Cancer, 2005,115 (4) : 503-510.
  • 9Bernal C, Aguayo F, Villarroel C, et al. Reprimo as a po- tential biomarker for early detection in gastric cancer[J]. Clin Cancer Res, 2008 ,14(19) :6'264-6269.
  • 10Takahashi Takao,Suzuki Makoto,Shigematsu Hisayuki,Shivapurkar Narayan,Echebiri Chinyere,Nomura Masaharu,Stastny Victor,Augustus Meena,Wu Chew-Wun,Wistuba Ignacio I,Meltzer Stephen J,Gazdar Adi F.Aberrant methylation of Reprimo in human malignancies. International journal of cancer. Journal international du cancer . 2005

引证文献3

二级引证文献7

中国医药导报
2013年 第35期

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