C-反应蛋白、D-二聚体及肌钙蛋白在诊断急性心血管病中的应用

The Application Value of C-Reactive Protein,D-Dimer and Troponin in the Diagnosis of Acute Cardiovascular Disease

目的对患者快速血液检测C-反应蛋白(CRP),D-二聚体(DD)及肌钙蛋白(cTnT)的含量进行初步诊断急性心血管疾病的类型及疾病的进展程度。方法选择符合急性心血管疾病的研究组:患者72例,包括急性冠脉综合症(ACS)组35例,非急性冠脉综合症(非ACS)组37例,其亚组包括主动脉夹层破裂(AD)组17例和肺动脉栓塞(PTE)组20例;非急性心血管疾病组为对照组40例。结果急性心血管疾病组的三种蛋白的含量明显高于非急性心血管疾病组;其中,AD和PTE组中C-反应蛋白,D-二聚体的含量明显升高,并且D-二聚体显著升高组AD可能性最大,另外肌钙蛋白在急性冠脉综合症患者中含量明显高于AD和PTE组。结论 C-反应蛋白,D-二聚体及肌钙蛋白的含量可以应用于急诊急性心血管疾病的初步筛查,显著提高急诊急性心血管疾病的确诊率。

Objective To make the preliminary diagnosis of acute cardiovascular disease types and the progression of disease. Selecting the patients to rapidly test blood content of C -reactive protein （CRP）, D -dimer （DD） and troponin （cTnT）. Methods Choose team meeting acute cardiovascular disease： 72 cases of patients, including 35 cases of acute coronary syndrome （ACS） group, the 37 cases of not acute coronary syndrome （ACS） group, including 17 cases of rup- tured aortic dissection （AD） group and 20 cases of pulmonary embolism （PTE） group. The not acute cardiovascular dis- ease group concluding 40 cases is the control group. Results The content of three kinds protein in the acute cardiovascular disease group was significantly higher than the not acute cardiovascular disease group; Among them, the C - reactive pro- tein and D - dimer in PTE and AD groups increased significantly, and the D - dimer remarkable raised reminds the largest possibility of AD group, and troponin levels were significantly higher than those in patients with AD and PTE groups. Con- clusion The content of C - reactive protein, D - dimer and troponin can be applied to the patients with acute cardiovascu- lar disease in the emergency department for preliminary screening, significantly improve the positive rate of emergency treat- ment of acute cardiovascular disease.