缩宫素与米索前列醇联合应用防治产后出血的临床观察

Clinical Observation of the Combined Application of Oxytocin and Misoprostol to Prevent and Treat Postpartum Hemorrhage

目的观察缩宫素联合米索前列醇预防产后出血的临床效果及安全性。方法选取本院生产的产妇150例,随机分为对照组和观察组,每组75例,对照组给予缩宫素,观察组给予缩宫素及米索前列醇,统计比较两组产前、产后的生理指标,产后出血率,产后30 min、2 h和24 h的累积出血量,常规时间指标及药物的不良反应发生率。结果两组产前产后血压、心率、血细胞计数、血红蛋白及不良反应发生率比较均无显著性差异(P>0.05),与对照组比较,观察组产后出血率及产后30 min、2 h、24 h的累积出血量明显下降(P<0.01),持续宫缩时间明显延长(P<0.01),第三产程时间、住院时间和恶露出血时间均明显缩短(P<0.01)。结论缩宫素联合米索前列醇可增强宫缩,预防产后出血效果好,安全性高,值得临床推广应用。

Objective To observe the clinical effect and safety of the combined application of oxytocin and misopros- tol to prevent and treat postpartum hemorrhage. Method 150 parturient women in our hospital were chosen as the sam- ples. They were divided into control group and observation group, randomly with 75 parturient women in each group. The control group was given oxytoein while the observation group was given misoprostol. Statistical comparisons were made be- tween two groups in terms of prenatal and postnatal physiological indexes, the rate of postpartum hemorrhage, postpartum bleeding amount of 30 min 2 h and 24 h, normal time index and the incidence of drug untoward effect. Results No signif- icant difference existed between the two groups in prenatal postpartum blood pressure, heart rate, blood counts, hemoglobin and incidence of untoward effect （P 〉 0. 05 ）. Compared with the control group, the observation group~ postpartum bleed- ing rate and postpartum bleeding amount of 30 rain, 2h and 24h declined dramatically （ P 〈 0. 01 ）. Continuous contractions time was obviously prolonged （P 〈0. 01 ）. The third stage of labor, hospital stays and lochia efflux time were significantly shortened （P 〈 O. 01 ）. Conclusion Oxytocin and misoprostol can enhance contractions and effectively prevent postpartum hemorrhage with high safety. It is worth clinically spreading and widely applying.