血清抗脂阿拉伯甘露糖抗体对活动性肺结核的诊断价值

CLINICAL VALUE OF ANTI-LIPOARABINOMANNAN ANTIBOBY IN SERUM FOR DIAGNOSIS OF ACTIVE PULMONARY TUBERCULOSIS

目的 评价抗 L AM- Ig G检测对活动性肺结核的诊断价值。方法 采用 L AM为抗原 ,DIGFA法检测 2 75例活动性肺结核 ,145例非活动性肺结核病人 ,135例非结核病人和 15 0例健康人血清中的L AM- Ig G。结果 活动性结核病组抗 L AM- Ig G阳性率 85 .1% ,其中菌阳为 93.8% ,菌阴组 80 .3% ,非活动性结核组 12例阳性 ,非结核组 10例阳性 ,健康组 11例阳性 :血清抗 L AM抗体诊断结核病的敏感性为 85 .1% ,特异性 92 .3% ,准确性 90 % ,阳性预测值 87.6 % ,阴性预测值 90 .6 %。结论 提示血清抗 L AM- Ig G测定可用于诊断活动性结核病。

Objective To evaluate the value of anti-lipoarabinomannan antiboby(LAM-IgG)detection in the diagnosis of pulmonary tuberculosis.Methods lipoarabinomannan of Mycobacterium tuberculosis were used as antigen to detect anti-LAM-IgG in serum by dot immunogold filtration assay(DIGFA).275 sera from patients with active pulmonary tuderculosis.145 sera from nonactive pulmonary tuberculosis.135 sera from without tubercuosis patients and 150 sera from health person were detected by DIGFA.Results The positive rate of anti-LAM-IgG was 85.1% in active pulmonary tuberculosis group,and the flase positive rate were 8.3%、7.4% and 7.1% in nonactive pulmolonary tuberculosis group and Without tuberculosis patients and health persons respectively.It was demonstrated that the sensitivity,Specificity and accuracy of the antibody to diagnosis tuberculosis were 85.1%、92.3% and 90%,while the positive and negative predictivities were 87.6% and 90.6% respectively.Conclusion The results suggested that detection of anti-LAM-IgG is helpful for diagnosing active pulmonary tuberculosis.