肝硬化患者上消化道出血与细菌感染的关系观察

Relationship between upper gastrointestinal bleeding and bacterial infection in patients with cirrhosis

目的 观察肝硬化患者上消化道出血与细菌感染的关系.方法 选取本院2010年11月～2013年4月收治的89例肝硬化患者,将89例患者根据出血情况分为两组,其中出血48例,未出血41例,分别在患者入院后第1、3、5天采集咽、尿、血、腹水等样本进行细菌培养观察,观察分析肝硬化患者上消化道出血与细菌感染的关系.结果 出血组细菌感染35例,感染率为72.9％,未出血组细菌感染22例,感染率为53.7％,两组感染率差异有统计学意义（P＜0.05）.出血组患者咽部和腹水部位感染率显著高于未出血组,差异有统计学意义（P＜0.05）.结论 肝硬化患者上消化道出血会导致细菌感染率增加,在临床治疗中,应引起足够重视,实施有针对性的抗菌治疗;同时注意采用抗生素做好预防性治疗,以有效防治静脉曲张所引发的上消化道出血,减少细菌感染的出现.

Objective To investigate the relationship between bacterial infection and upper gastrointestinal bleeding in patients with liver cirrhosis.Methods 89 cases of patients with liver cirrhosis in our hospital from November 2010 to April 2013 were selected and divided into two groups according to bleeding or no,including 48 cases in bleeding groupA1 cases in no bleeding group,On the first,third,fifth day,the sample of pharynx,urine,blood and ascites were selected and given bacterial culture,the relationship between bacterial infection and upper gastrointestinal bleeding in patients with liver cirrhosis were observed and compared.Results 35 cases in bleeding group were found with bacterial infection,the infection rate was 72.9%,22 cases in no bleeding group were found with bacterial infection,the infection rate was 53.7%,infection rate of two groups compared,the difference was significant（P〈0.05）.The infection rate of pharynx and aseites in bleeding group were higher than those in no bleeding group,the difference was significant （P〈0.05）. Conclusion Upper gastrointestinal bleeding in patients with cirrhosis can increase bacterial infection rate,in the clinical treatment,enough attention should be paid,the implementation of targeted antibiotic treatment and antibiotics preventive treatment can effectively prevent the upper gastrointestinal bleeding caused by varicose vein disease,and reduce the bacterial infection rate.