肾综合征出血热患者血清C反应蛋白动态变化

Dynamic changes of CRP in serum of HFRS patients

目的 :了解肾综合征出血热 (HFRS)患者血清C反应蛋白 (CRP)的动态变化 ,探讨其在HFRS发病中的意义。方法 :用速率比浊法检测 39例HFRS患者和 39例正常人血清CRP含量。结果 :HFRS患者血清CRP水平明显高于对照组 (P <0 0 1 ) ,且于发热早期已增高 ,低血压期、少尿期达高峰 ,多尿期、恢复期逐渐下降至正常水平。危重型患者发热期、低血压期、少尿期较轻型、中型患者血清CRP水平明显增高(P <0 0 1 )。HFRS患者CRP水平与血小板计数呈明显负相关 (P <0 0 1 ) ,与尿蛋白、BUN呈明显正相关 (P <0 0 1 )。结论 :HFRS患者血清CRP水平与病程进展和病情轻重密切相关 ,早期动态检测对估计病情和判断预后有重要意义。

Objective:In order to study the dynamic changes of C-reactive protein (CRP) in the serum of heamorrhagic fever with renal syndrome (HFRS) patients,as well as the role in the pathogenesis of HFRS.Methods:Rate turbimetric was used to examine the content of CRP in serum from 39 HFRS patients in different stage and a group of 30 normal persons.Results:The CRP level in the HFRS patients was significantly higher than that in the control group (P<0 01),it was already higher in the early period of febril,and was the highest during the hypotensive and oliguric phases.The level would come down gradually to normal during diuretic and convalescent phases.The analysis showed that the CRP level of severe and critical cases was significantly higher than that of the mild and moderate cases in fever,hypotentive,and oliguris phases (P<0 01).The related analysis showed that there was a negative correlation between the CRP level in serum and platelet quantity (P<0 01),and was a posistive correlation with the increased concentration of BUN and urine protien (P<0 01).Conclusions:To HFRS patients,the CRP level in serum was closely related to the course and seriousness of this disease.The early dynamic detecting plays an important role in the estimation of the severity and prognosis of HFRS.