血尿酸水平与血压水平及高血压相关性的研究

Study on the pertinence between uric acid level and blood pressure level and hypertension

目的：通过研究血尿酸与高血压的相关性,探讨血尿酸水平与高血压之间的关系.方法：以北京市20万自然人群中35 ～64岁的随机分层抽取横断面调查资料为基础,通过对其中未服降压药物的1 021例进行分析,并于2004年对1999年调查人群中进行了复查,本研究通过对两次收集的资料进行分析,探讨血尿酸与血压水平、高血压患病率及发病率的相关性.结果：血尿酸和血压水平存在相关（收缩压r =0.220,P＜0.001；舒张压r=0.291,P＜0.001）,血尿酸水平与血压水平的上升方向一致,血压水平随血尿酸水平的升高而上升,血尿酸水平与高血压患病率相关,随着尿酸分层上升,高血压患病率及相对危险呈上升趋势.调整了年龄、TC、TG、HDL-C和BMI后,其相关性及趋势依然存在.基线血清尿酸水平与5年间新发高血压相关,5年间高血压的发病率随基线血清尿酸水平的升高而呈上升趋势.结论：血尿酸和血压水平存在关联,血尿酸水平与高血压患病率相关.高血压患病率及发病率随尿酸水平的升高而增加.

Objective：Investigate the relationship between serum UA level and hypertension, analyzing the consistency, pertinence and possible consequence of changes in UA level and hypertension. Methods： A population-based sample of 1 021 subjects aged 35 -64 years was selected from 200 000 natural population in Beijing using stratified random sampling method, and a cross-sectional study was carried out. In 2004, subjects participated the 1999 cross-sectional study were rechecked, This study analyzed the data collected from the two surveys explored the pertinence between UA level and blood pressure level and incidence rate of hypertension. Results ： A positive association was found between serum UA level and blood pressure level （ systolic pressure, r = 0. 220, P 〈 0. 001 ; diastolic pressure, r = 0. 291, P 〈 0. 001 ） in our study population. Blood pressure level increased with elevated Serum uric acid level. Serum uric acid level was correlative with prevalence rate of hy- pertension. The prevalence rate of hypertension increased along with the increase of serum UA level. ： After ad- justing age and TC, TG, HDL-C and BMI, serum UA level was still correlative with prevalence rate of hyper- tension. People with higher serum uric acid level had higher risk to become hypertension in five years period. Conclusion：Serum UA level was correlated with blood pressure level, Serum UA level was found to be associat- ed with prevalence rate of hypertension. The prevalence rate of hypertension was increased with the increase of serum UA level.