肝硬化患者血小板与血清前白蛋白联合检测的分析

Clinical significance of the platelet test and the elevated serum PA forpatients with Liver cirrhosis

目的分析肝硬化患者血小板与血清前白蛋白检测的意义。方法采用日本光电MEX-7222K全自动五分类血液分析仪检测82例来自我院2010年9月至2012年9月传染科肝硬化患者血小板4项参数(PLT、MPV、PDW、PCT),用透射免疫比浊法检测血清白蛋白(PA)并与70名正常对照组进行比较。结果肝硬化患者的PLT、PCT和PA较正常对照明显降低,差异具有统计意义(P<0.01〉;MPV及PDW明显升高与正常对照差异有统计意义(P<0.01〉。并且随着Child-Pugh分级的增加PLT,PCT及PA降低程度更加明显。结论血小板4项参数对评估肝硬化的严重程度及出血倾向有重要意义,血清前白蛋白PA异常变化可反映肝脏损伤程度对肝硬化患者的临床诊断、治疗具有一定的参考价值。

Objective To analyse the clinical significance of platelet and PA test for patients with liver cirrhosis. Methods Levels of platelet （ PLT）, mean platelet volum （ MPV ）, platelet distribution width （ PDW ）, plateletcrit （PCT） for 82 patients with liver cirrhosis, those whowere selected as the research objectfrom June 2010 to June 2012 in our hospital, were tested by using Japanese photoelectric MEK-7222K automatic five classification blood analyzer. The level of serum prealbumin was detected by transmissionimmunoturbidimetry method. And compared the levels with the control group. Results The levels of PLT, PCT, PA of patients with liver cirrhosis were significantly reduced and the levels of MPV, PDW of patients with liver cirrhosiswere significantly increased compared with control group （ P 〈 0. 01 ）. The levels of PLT, PCT, PA of patients with liver eirrhosisdecreased significantly as the Child-pugh degreeraised. Conclusions The detection of PLT,PCT,PA had great significance for evaluation of cirrhosis severity and bleeding tendency. And levels of PA in serum could reflect the condition of liver damnification, and helpful for clinical diagnosis and treat for patients with liver cirrhosis.