初诊高血压患者白细胞内硫化氢产生速率及相关炎性因子变化的研究

A research about the leukocytic productivity of hydrogen sulfide and related cytokines before and after the blood pressure be controlled

目的调查初诊高血压患者未用药前与血压控制后白细胞内硫化氢(H_2S)产生速率的变化,并探讨其影响血压的可能机制。方法选取初诊高血压患者45例,通过测量其未用药前与血压控制后白细胞H_2S产生速率及血浆高血压相关炎性因子的浓度,分析高血压控制前后白细胞内H_2S产生速率的变化,并探讨其对高血压相关炎性因子的影响。结果初诊高血压患者血压控制后较未用药前白细胞内H_2S产生速率明显增加,且血浆内高血压相关炎性因子明显降低。结论白细胞内产生的H_2S可能是调节人体血压的重要因素,且其可能通过影响高血压相关炎性因子的产生影响血压调节。

Objective To investigate the change of the hypertensive patients＇ leukocytic productivity of hydrogen sulfide before treatment and ＇after the blood pressure be controlled, and to explore the mechanisms in the regulation of hypertension. Method We selected 45 cases of hypertensive without treatment, acquired the blood samples before treatment and after the blood pressure is controlled. Then we measured the leukocytic productivity of hydrogen sul- fide and the plasma cytokines related to hypertension, analyzed the change of the leukocytic productivity of hydrogen sulfide and its influence on the cytokines related to hypertension. Result The leukocytic productivity of hydrogen sulfide after the blood pressure be controlled is significantly higher than before treatment, the plasma cytokines related to hypertension are significantly lower before treatment than after the blood pressure be controlled. Conclusion The leukocytic productivity of hydrogen sulfide maybe an important factor in the regulation of blood pleasure. It may play the role of regulating blond pressure via its impact on eytokines related to hypertension.