半乳糖凝集素-3在心力衰竭诊断及预后中的应用价值

Application value of galectin-3 in the diagnosis and prognosis of heart failure

目的 探讨半乳糖凝集素-3（Gal-3）在心力衰竭诊断及预后判断中的价值.方法 选择68例心力衰竭患者（心力衰竭组）和68例健康体检者（对照组）,比较两组及不同心功能分级心力衰竭患者Gal-3水平和随访6个月后的心血管事件发生率.结果 心力衰竭组Gal-3水平为（44.57±10.42）ng/L,对照组为（33.76±8.18）ng/L,两组比较差异有统计学意义（P＜0.01）.心功能分级Ⅳ级（15例）的心力衰竭患者Gal-3水平及随访6个月后的心血管事件发生率显著高于心功能分级Ⅱ级（32例）和Ⅲ级（21例）患者[（46.45±12.21） ng/L比（38.47±9.38）、（42.31±10.23） ng/L,8/15比9.4％（3/32）、28.6％（6/21）],差异有统计学意义（P＜0.01）.结论 Gal-3可作为心力衰竭患者诊断及预后判断的标志物之一,且其水平与心功能分级有相关性.

Objective To evaluate the value of galectin-3 （Gal-3） in the diagnosis and prognosis of heart failure.Methods Sixty-eight patients with heart failure （heart failure group） and 68 healthy person （control group） were selected.The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up was compared between two groups and among different cardiac functional grading.Results The level of Gal-3 was （44.57 ± 10.42） ng/L in heart failure group,（33.76 ± 8.18） ng/L in control group,and there was significant difference between two groups （P 〈 0.01）.The level of Gal-3 and the incidence of cardiovascular event after 6 months follow-up in cardiac functional grading Ⅳ （15 cases） was higher than that in cardiac functional grading H （32 cases）,Ⅲ （21 cases）[（46.45 ± 12.21） ng/L vs.（38.47 ±9.38）,（42.31 ± 10.23） ng/L,8/15 vs.9.4%（3/32）,28.6%（6/21）],and there was significant difference （P 〈0.01）.Conclusion As the marker of heart failure,the Gal-3 has significantly clinical value on diagnosis and prognosis to segment heart failure.